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P0244 - Chaotic neural response reflecting stroop incongruent task is related to serum Cortisol levels in patients with unipolar depression

Published online by Cambridge University Press:  16 April 2020

M. Susta ,
P. Bob ,
J. Pavlat ,
T. Zima ,
H. Benakova  and
J. Raboch
M. Susta
Affiliation:
Department of Psychiatry, First Faculty of Medicine, Charles University, Prague, Czech Republic
P. Bob
Affiliation:
Department of Psychiatry, First Faculty of Medicine, Charles University, Prague, Czech Republic
J. Pavlat
Affiliation:
Department of Psychiatry, First Faculty of Medicine, Charles University, Prague, Czech Republic
T. Zima
Affiliation:
Department of Clinical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University, Prague, Czech Republic
H. Benakova
Affiliation:
Department of Clinical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University, Prague, Czech Republic
J. Raboch
Affiliation:
Department of Psychiatry, First Faculty of Medicine, Charles University, Prague, Czech Republic

Abstract

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Background and Aims:

According to recent findings detecting a cognitive conflict is related to activation of anterior cingulate cortex (ACC) and central autonomic network. Several recent findings also suggest the hypothesis that the cognitive conflict is related to specific nonlinear chaotic changes of the neural signal. This conflict related activation elicits autonomic responses which can be assessed by psychophysiological measures such as heart rate variability calculated as beat to beat R-R intervals (RRI).

Method:

The present study used Stroop word-colour test as an experimental approach to psychophysiological study of cognitive conflict in connection with RRI measurement, assessment of serum cortisol and calculation of largest Lyapunov exponents in nonlinear data analysis of RRI time series in 32 patients with unipolar depression.

Result:

Significant correlation –0.43 (p<0.01) between largest Lyapunov exponents during conflicting Stroop task and serum cortisol levels has been found.

Conclusion:

The study indicates that a defect of neural inhibition during conflicting Stroop task is closely related to decreased serum cortisol levels which probably reflect defense psychological mechanisms.

Type
Poster Session II: Depression
Information
European Psychiatry , Volume 23 , Issue S2: 16th AEP Congress - Abstract book - 16th AEP Congress , April 2008 , pp. S264
Copyright
Copyright © European Psychiatric Association 2008
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