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P02-280 - The Combination of Amisulpiride and Clozapine for the Treatment of Treatment-Resistant Schizophrenia

Published online by Cambridge University Press:  17 April 2020

C. Istikoglou ,
D. Foutsitzis ,
F. Papouli ,
N. Polonifis ,
P. Kanellos ,
G. Theodorakopoulos ,
J. Kogeorgos ,
D. Vlissides ,
K. Michelidakis  and
T. Salla
C. Istikoglou
Affiliation:
Psychiatric Department,’Konstantopouleio’ General Hospital of Nea Ionia, Athens, Greece
D. Foutsitzis
Affiliation:
Psychiatric Department,’Konstantopouleio’ General Hospital of Nea Ionia, Athens, Greece
F. Papouli
Affiliation:
Psychiatric Department,’Konstantopouleio’ General Hospital of Nea Ionia, Athens, Greece
N. Polonifis
Affiliation:
Psychiatric Department,’Konstantopouleio’ General Hospital of Nea Ionia, Athens, Greece
P. Kanellos
Affiliation:
Psychiatric Department,’Konstantopouleio’ General Hospital of Nea Ionia, Athens, Greece
G. Theodorakopoulos
Affiliation:
Psychiatric Department,’Konstantopouleio’ General Hospital of Nea Ionia, Athens, Greece
J. Kogeorgos
Affiliation:
Psychiatric Department,’Konstantopouleio’ General Hospital of Nea Ionia, Athens, Greece
D. Vlissides
Affiliation:
Psychiatric Department,’Asklepeio’ General Hospital of Voula, Athens, Greece
K. Michelidakis
Affiliation:
Psychiatric Department,’Asklepeio’ General Hospital of Voula, Athens, Greece
T. Salla
Affiliation:
Psychiatric Department,’Konstantopouleio’ General Hospital of Nea Ionia, Athens, Greece

Abstract

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Objectives

Treatment-resistant schizophrenia is an old term, describing the form of schizophrenia that does not respond to a treatment dose of Chloropromazine, equal to 1,5 gr.

Methods

20 (n=20) patients have been studied, that were diagnosed with schizophrenia, and did not respond to any combination of typical or non-typical anti-psychotic drugs. These patients were 19-62 years of age, and were administered the BPRS and PANSS scales at start of the examination or the hospitalization, and during the 1st, 3rd, and 6th month evaluation. The said patients were treated with a combination of Amisulpiride, and Clozapine.

Results

The patients received a dosage range of 400-1200mg for the Amisulpiride, and 300-900mg for the Clozapine. 18 patients (90%) responded to this treatment, and showed an improvement in the BPRS and PANSS scales, from the 1st month of treatment using a combination of Amisulpiride-Clozapine. Later, during the 3rd month of treatment, one of the patients discontinued the treatment, as she presented leucopenia (white cell count: 3250). The discontinuation of Clozapine treatment was decided. Clozapine was replaced by 20mg Olanzapine.

Conclusions

Despite the fact that the sample of patients was very small (n=20), it seems that the combination of Amisulpiride and Clozapine is effective for the treatment of patients showing resistance in pharmaceutical treatment and the combination of typical and non-typical neuroleptics.

Type
Prevention of mental disorders
Information
European Psychiatry , Volume 25 , Issue S1: 18th European Congress of Psychiatry. February 27, March 2, 2010 - Munich, Germany , 2010 , 25-E906
Copyright
Copyright © European Psychiatric Association 2010
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