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P01-76 - An Audit to Compare the Discharge Rates between Different Antidepressant Monotherapies Prescribed for Unipolar Depression

Published online by Cambridge University Press:  17 April 2020

M. Agius ,
J. Gardner ,
K. Liu  and
R. Zaman
M. Agius
Affiliation:
Psychiatry, Bedfordshire and Luton Partnership Trust, Luton Psychiatry, UK
J. Gardner
Affiliation:
Clinical School, University of Cambridge, Cambridge, UK
K. Liu
Affiliation:
Clinical School, University of Cambridge, Cambridge, UK
R. Zaman
Affiliation:
Psychiatry, Bedfordshire and Luton Partnership Trust, Bedford Psychiatry, University of Cambridge, Cambridge, UK

Abstract

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Background

A recent metanalysis has demonstrated that there are differences in efficacy and acceptability of commonly prescribed anti-depressants (Cipriani et al. 2009). Escitalopram, sertraline, venlafaxine and mirtazapine were the most effective.

Objective

We wished to find out whether the data from our own practice corresponded with the data from the metanalysis.

Aim

To compare the efficacy of anti-depressant monotherapies in patients with unipolar depression at Bedford Hospital, using discharge rates as the outcome measure.

Method

We included all patients with unipolar depression on an antidepressant monotherapy in Bedford hospital in our analysis (145 in total). We examined the clinical notes for each patient to assess whether they had been discharged from the out-patient clinic after being prescribed the antidepressant. This allowed us to calculate discharge rates for each antidepressant monotherapy.

Results

A higher percentage of patients prescribed Escitalopram were discharged from clinic compared to theother anti-depressant monotherapies.

Discussion

Our results support the findings of the meta-analysis. The discharge rates from Bedford hospital suggest that Escitalopram in particular is the most efficacious.

Conclusion

This audit in a small group of patients suggests that Escitalopram leads to the highest discharge rate compared to the other monotherapies prescribed.

Type
Affective disorders / Unipolar depression / Bipolar disorder
Information
European Psychiatry , Volume 25 , Issue S1: 18th European Congress of Psychiatry. February 27, March 2, 2010 - Munich, Germany , 2010 , 25-E295
Copyright
Copyright © European Psychiatric Association 2010

References

Cipriani, A., Furukawa, T.A., Salanti, G., Geddes, J.R., Higgins, J.P., Churchill, R., Watanabe, N., Nakagawa, A., Omori, I.M., McGuire, H., Tansella, M., Barbui, C. Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis. Lancet 2009Feb 28; 373(9665): 746–758Google Scholar
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