P0170 - Obsessive-compulsive disorders in patients with schizophrenia

Abstract

Obsessive-compulsive disorder is a prevalent and clinically significant phenomenon in schizophrenia patients. It is estimated that 7.8%–46.6% of patients with schizophrenia also have obsessive-compulsive symptoms. Both schizophrenia and obsessive-compulsive disorder (OCD) are considered to be neurodevelopment disorders sharing dysfunctional frontal-subcortical circuitry.

The aim of the present study was to determine the rate of obsessive-compulsive disorder (OCD) in patients with schizophrenia never treated. We also examined the relationship of obsessive-compulsive symptoms to schizophrenic symptoms.

It is a prospective study on a sample of schizophrenics patients never treated in the Academic Psychiatric service of Marrakech since January 2007.

We have valued 31 patient, the instruments used were the Structured Clinical Interview for DSM-IV-R, the positive and negative symptoms scale (PANSS) and Yale-Brown Obsessive Compulsive Scale.

The middle age of patients is of 27.35 years with a predominance masculine (93.5%). the majority (87.1%) without profession;

Seven of the 31 patients (22.6%) met the DSM-IV-R criteria for both obsessive-compulsive disorder and schizophrenia.

Identification of OCD in schizophrenia patients may have neurobiological, prognostic, and therapeutic implications.