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P01-42 - G72/G30 Candidate Gene for Bipolar I Disorder is not Associated with Psychosis in the Romanian Population

Published online by Cambridge University Press:  17 April 2020

M. Grigoroiu-Serbanescu ,
S. Herms ,
C.C. Diaconu ,
C. Bleotu ,
A.I. Neagu ,
R. Abou Jamra ,
M. Gherghel ,
D. Sima ,
I.A. Dan  and
D. Prelipceanu
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M. Grigoroiu-Serbanescu
Affiliation:
Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania
S. Herms
Affiliation:
Department of Genomics, Life & Brain Center, Institute of Human Genetics, University of Bonn, Bonn, Germany
C.C. Diaconu
Affiliation:
Stefan S Nicolau Institute of Virology, Romanian Academy, Romania
C. Bleotu
Affiliation:
Stefan S Nicolau Institute of Virology, Romanian Academy, Romania
A.I. Neagu
Affiliation:
Stefan S Nicolau Institute of Virology, Romanian Academy, Romania
R. Abou Jamra
Affiliation:
Department of Genomics, Life & Brain Center, Institute of Human Genetics, University of Bonn, Bonn, Germany
M. Gherghel
Affiliation:
Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania
D. Sima
Affiliation:
Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania
I.A. Dan
Affiliation:
Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania
D. Prelipceanu
Affiliation:
Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania
M.M. Nöthen
Affiliation:
Department of Genomics, Life & Brain Center, Institute of Human Genetics, University of Bonn, Bonn, Germany
S. Cichon
Affiliation:
Department of Genomics, Life & Brain Center, Institute of Human Genetics, University of Bonn, Bonn, Germany

Abstract

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Background

The G72/G30 gene is one of the common loci shared both by schizophrenia and bipolar disorder. Studies accumulating since the discovery of this gene complex in 2002 produced controversial results in both disorders in different populations.

Objective

We investigated the association between G72/G30 gene and bipolar I disorder (BPI) in the Romanian population paying special attention to the association of G72/G30 locus with lifetime psychosis in BPI patients.

Method

Fourteen G72-SNPs were genotyped in a Romanian sample of 198 BPI patients and 180 controls screened for psychiatric disorders in the Institute of Human Genetics, Life & Brain Center of the University of Bonn, Germany. Statistical analysis was performed with FAMHAP and Haploview-v3.32. The significance level of the results was corrected for multiple testing through permutations in 100,000 Monte Carlo simulations.

Results

None of the fourteen SNPs was associated with the global diagnosis of BPI in our total patient sample or with the psychotic BPI subtype. But four SNPs reached nominal significance in the non-psychotic BPI subgroup [rs3916965 (M12) (P=0.044), rs1935057 (P=0.037), rs3916967 (M14) (P=0.043), rs2391191 (M15, non-synonymous) (P=0.043)]. In the non-psychotic subgroup, the haploblock including M14 and M15 (GA) remained significantly associated with BPI after correction through permutations (P=0.0524; OR=1.82).

Conclusion

Our results are the first replication of the study by Williams et al. (2006) reporting the same G72-SNPs [M12(A) and the functional SNP M15(A)], with the same alleles, to be associated with non-psychotic BPI disorder.

Type
Affective disorders / Unipolar depression / Bipolar disorder
Information
European Psychiatry , Volume 25 , Issue S1: 18th European Congress of Psychiatry. February 27, March 2, 2010 - Munich, Germany , 2010 , 25-E261
Copyright
Copyright © European Psychiatric Association 2010
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