P0132 - Familial loading in bipolar disorder and substance use disorder

Abstract

Background:

Bipolar disorder and substance use disorder have well documented genetic component. Among Axis I disorder bipolar subjects have highest comorbidity for alcohol and substance use disorder, ranging from 17 to 60%. Some Authors find a familial association between bipolar disorder and substance use disorder, suggesting the question if these disorders share a common genetic liability.

Aims:

To investigate familial loading in bipolar disorder (with and without alcohol/substance use disorder) and in patients with substance use disorder.

Methods:

Sampe (62 patients with bipolar disorder and alcohol/substance use disorder-DD, 23 patients with bipolar disorder-BD, 22 patients with substance use disorder without mood disorder-SUD) was recruited in Psichiatric clinic of Pisa and Dependance Department of Pisa and Bolzano. Instruments: SCID-IV-I/P for Axis I diagnosis and Family History Screen (Weissman, 2000).

Results:

Bipolar pts (DD and BD) have higher familial diathesis for manic and depresive episodes respect DUS probands (p≤0.001). Moreover DD show higher familial loading for alcohol/substance use respect BD (p=0.000). Abuser subjects (DD and SUD) show higher familiarity for conduct disorder respect BD (p=0.008)

Conclusions:

DD pts show a double familial loading, both for mood disorder (respect SUD), and for alcohol/substance use disorder (respect BD). Probably the familial loading for substance use disorder and mood disorder are distinct and they are both present in dual diagnosis patients.