P0132 - Childhood subclinical characteristics in schizophrenia - a questionnaire-based retrospective study

Abstract

Background and Aims:

Childhood subclinical characteristics have not been fully investigated in patients with schizophrenia. To elucidate the picture of them, and to find out indicators which predict later development of schizophrenia, childhood behaviors of the adult schizophrenia subjects were investigated in a questionnaire-based retrospective study.

Population and Methods:

schizophrenia outpatients (n=50) in his/her twenties and normal healthy subjects (n = 100) were investigated. All patients are diagnosed according to DSM-IV-TR as schizophrenia, and who presents now mainly negative symptoms after passing an acute stage. By modified use of the Child Behavior Checklist (CBCL) as a retrospective assessment questionnaire, the parents of the patients and of control subjects rated their childhood behavior.

Results:

A discriminant analysis using all items of CBCL correctly classified 99.0% of the population. Notable in an item-level analysis was an extremely attenuated aggression in personal relations in the schizophrenia subjects. Among eight subscales of the CBCL, those of Withdrawal, Social Problems, Attention Problems and Aggressive Behavior contributed most to the accuracy of the prediction of group membership.

Conclusions:

It was suggested that subclinical behavioral and psychological characteristics of schizophrenia already exist in the patients' childhood, among which lack of aggressive behaviors might be one of the core features.