P0020 - Clinical-Immunological criteria of prognosis of prolonged course of posttraumatic stress disorders

Abstract

70 men have been examined – participants of military actions in Caucasus with PTSD. According to type of course and duration of disease patients have been divided into 2 groups: 1–acute-subacute course of PTSD, duration of disease not more than 3 years (36 persons); 2–prolonged course of PTSD, duration of disease 4 and more years (34 persons).

Clinical signs of secondary immune deficiency have been revealed in 58,6% of exam-ined of group 1 and in 78,6% - group 2. In group 2, combination of several syndromes of im-mune deficiency is observed.

During comparison of incidence of accompanying somatic diseases pathology of vari-ous systems in group 1 has been noticed in 63,2% of combatants, in group 2, somatic pathol-ogy has been revealed in 100% of combatants. In patients with prolonged course of PTSD in anamnesis we have noticed fighting traumata and contusions - 60,0%. In patients of group 1 - 39,5%.

Significant differences have been identified between parameters of the immunity in pa-tients of examined groups. Immune status of combatants with prolonged course of PTSD as compared with the group 1 was characterized by lower values of number of T-lymphocytes - CD3+(р<0,05), natural killers - CD16+(р<0,05); higher values of number of B-lymphocytes and activated T-lymphocytes HLADR+(р<0,05), level of circulating immune complexes (р<0,01).

Revealed differences of indices of immune status between examined groups of combat-ants, presence of clinical signs of immune deficiency and accompanying somatic pathology allow considering complex of these factors as predictors of prolonged course of posttraumatic stress disorders.