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Oxidative stress and brain glutamate-mediated excitability in depressed patients

Published online by Cambridge University Press:  16 April 2020

C. Salustri ,
R. Squitti ,
F. Zappasodi ,
M. Ventriglia ,
M.G. Bevacqua ,
M. Fontana  and
F. Tecchio
C. Salustri
Affiliation:
Institute of Cognitive Sciences and Technologies (CNR), Italy
R. Squitti
Affiliation:
Dept. of Neuroscience, AFaR, Fatebenefratelli Hospital, Rome, Italy
F. Zappasodi
Affiliation:
Dept. of Clinical Sciences and Bioimaging, Gabriele d’Annunzio University, Chieti, Italy
M. Ventriglia
Affiliation:
Dept. of Neurology, Campus Biomedico University, Italy
M.G. Bevacqua
Affiliation:
Dept. of Neuroscience, Fatebenefratelli Hospital, Rome, Italy
M. Fontana
Affiliation:
Dept. of Neuroscience, Fatebenefratelli Hospital, Rome, Italy
F. Tecchio
Affiliation:
Dept. of Imaging, San Raffaele Cassino, Cassino (FR), Italy

Abstract

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Introduction

Several neuropsychiatric pathologies have been recently linked to oxidative stress.

Objectives

In this study, we investigated the relationship between depression, markers of oxidative stress and neurotransmission, as expressed by sensory cortex excitability.

Methods

Serum levels of oxidative stress markers and somatosensory magnetic fields, evokedby external galvanic stimulation, were measured in 13 depressed patients and 13 controls.

Results

Depressives had higher levels of total and free copper than controls and lower levels oftransferrin. They also showed lower sensory cortex excitability, which correlated with copperlevels in controls, but not in patients. Transferrin correlated with sensory cortex excitability inboth patients and controls, although in opposite ways. Copper level results associated with thepatients’ clinical status.

Conclusions

Pro-oxidant agents appear to affect neuronal excitability and clinical state ofdepressed patients, as free copper excess alters their cortical glutamatergic neurotransmission.

Type
P02-31
Information
European Psychiatry , Volume 26 , Issue S2: Abstracts of the 19th European Congress of Psychiatry , March 2011 , pp. 626
Copyright
Copyright © European Psychiatric Association 2011
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