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Oxidative stress – A promising candidate in explaining the neurobiology of autism spectrum disorders

Published online by Cambridge University Press:  23 March 2020

M. Bækgaard Thorsen ,
N. Bilenberg ,
E. Benedikz ,
Å. Fex Svenningsen ,
P. Munk-Jørgensen  and
T. Sheldrick-Michel
M. Bækgaard Thorsen*
Affiliation:
Psychiatric Hospital and University of Southern Denmark, Psychiatric Research Academy Odense, Odense, Denmark Psychiatric Hospital and University of Southern Denmark, Research Unit of Psychiatry Odense, Odense, Denmark
N. Bilenberg
Affiliation:
Psychiatric Hospital and University of Southern Denmark, Research Unit of Child, and Adolescent Psychiatry Odense, Odense, Denmark
E. Benedikz
Affiliation:
Institute of Molecular Medicine, University of Southern Denmark, Department of Neurobiology Research, Odense, Denmark
Å. Fex Svenningsen
Affiliation:
Institute of Molecular Medicine, University of Southern Denmark, Department of Neurobiology Research, Odense, Denmark
P. Munk-Jørgensen
Affiliation:
Psychiatric Hospital and University of Southern Denmark, Psychiatric Research Academy Odense, Odense, Denmark
T. Sheldrick-Michel
Affiliation:
Psychiatric Hospital and University of Southern Denmark, Research Unit of Psychiatry Odense, Odense, Denmark
*
*Corresponding author.

Abstract

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Introduction

The diagnoses of autism spectrum disorders (ASDs) are based on a phenotype, characterized by impaired social interaction and communication and by repetitive and restricted interests. However, this might not represent a single clinical entity, but a behavioral manifestation of different neurodevelopmental deficits with a multifactorial etiology. Small studies have shown elevated levels of oxidative stress and lower levels of anti-oxidants in patients with ASD, and correlations with the severity of ASD. Therapies targeting oxidative stress have shown improvements regarding behavior, social interaction and verbal communication in patients with ASD, supporting the oxidative stress theory.

Objectives

To evaluate the importance of oxidative stress in the neurobiology of adults with ASD.

Aims

There is a need to understand the neurobiology of ASD, therefore this study analyzes the level of oxidative stress in a larger cohort of patients with ASD and compares to controls.

Methods

The study includes 350 patients over 18 years of age diagnosed with ICD-10 diagnoses F84.0, F84.1, F84.5 or F84.8 and compared to gender and age matched neurotypical controls. The included probands will have their serum and plasma analyzed for levels of oxidative stress (superoxide dismutase 1 and 2, catalase, glutathioneperoxidase, malonialdehyde, thiobarbituric acid reactive substances and xanthinoxidase).

Results

The preliminary results will be presented at the EPA in March 2016 in Madrid.

Conclusion

With this study we aim to elucidate some of the neurobiology in ASD. This could lead to new potential targets for treatment and prevention of the disorders.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
EW274
Information
European Psychiatry , Volume 33 , Issue S1: Abstracts of the 24th European Congress of Psychiatry , March 2016 , pp. S182
Copyright
Copyright © European Psychiatric Association 2016
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