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Oral glucose tolerance tests in treated patients with schizophrenia.

Data to support an adaptation of the proposed guidelines for monitoring of patients on second generation antipsychotics?

Published online by Cambridge University Press:  16 April 2020

Marc De Hert ,
Dominique Van Eyck ,
Linda Hanssens ,
Hendrik Peuskens ,
Erik Thys ,
Martien Wampers ,
Andre Scheen  and
Jozef Peuskens
Marc De Hert*
Affiliation:
University Centre Sint-Jozef, Katholieke Universiteit Leuven, Leuvensesteenweg 517, 3070Kortenberg, Belgium
Dominique Van Eyck
Affiliation:
University Centre Sint-Jozef, Katholieke Universiteit Leuven, Leuvensesteenweg 517, 3070Kortenberg, Belgium
Linda Hanssens
Affiliation:
Department of Epidemiology and Public Health, University of Liége, Liége, Belgium
Hendrik Peuskens
Affiliation:
University Centre Sint-Jozef, Katholieke Universiteit Leuven, Leuvensesteenweg 517, 3070Kortenberg, Belgium
Erik Thys
Affiliation:
University Centre Sint-Jozef, Katholieke Universiteit Leuven, Leuvensesteenweg 517, 3070Kortenberg, Belgium
Martien Wampers
Affiliation:
University Centre Sint-Jozef, Katholieke Universiteit Leuven, Leuvensesteenweg 517, 3070Kortenberg, Belgium
Andre Scheen
Affiliation:
Service of Diabetology, CHU de Sart Tilman, University de Liége, Liége, Belgium
Jozef Peuskens
Affiliation:
University Centre Sint-Jozef, Katholieke Universiteit Leuven, Leuvensesteenweg 517, 3070Kortenberg, Belgium
*
*Corresponding author. Tel.: +32 2 758 0546; fax: +32 2759 5380. E-mail address: [email protected] (M. De Hert).
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Abstract

Objective

A recent consensus conference has proposed guidelines for the monitoring for diabetes in patients with schizophrenia and also identifies the need of long-term prospective studies.

Methods

A large scale prospective study on metabolic risks of antipsychotic medication is currently ongoing. At baseline, patients get a full laboratory screening, ECG and an oral glucose tolerance test (OGTT). Baseline data on 100 non-diabetic patients at study inclusion and stable on medication for at least 6 months are presented.

Results

Glucose abnormalities are found in 22% of patients at baseline. A monitoring protocol based only on fasting glucose would not have detected 63.6% of these patients with classifiable glucose abnormalities in our sample. Fasting insulin and measures for insulin resistance have a high predictive value for abnormalities late in the OGTT.

Conclusions

Already at baseline, metabolic problems are frequently present in patients with schizophrenia treated with antipsychotics. Adding assessment of fasting insulin in a monitoring protocol improves detection of glucose abnormalities late in an OGTT.

Keywords

SchizophreniaDiabetesMetabolic syndromeAntipsychotics
Type
Original articles
Information
European Psychiatry , Volume 21 , Issue 4 , June 2006 , pp. 224 - 226
Copyright
Copyright © European Psychiatric Association 2006

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