Optimization of therapy clinic-immunological disorders with heroin addiction

Abstract

The immune defect can be found in all forms of addiction (Frank, 2004). These data determine the use of funds in immunotropic heroin addiction.

Objective

To study the effectiveness of antidepressant sevpram (citalopram) and its combination with galavit (imunomodulyator) on a background of standard pharmacotherapy in heroin addiction. To evaluate the immune status of the following methods:

– evaluation of lymphocytes (CD4), (CD8) with monoclonal antibodies in cytotoxicity assay;

– determination of serum immunoglobulin classes A, M, G performed by turbidimetric analysis;

– the concentration of the CIK (circulating immunnokompleks) was determined by precipitation with polyethylene glycol.

Patients of the 1st group was administered into the sevpram 10 mg/day in combination with galavit (25 mg daily); group 2 – only the standard therapy (ST).

The results of research

As a result of the treatment in the first group showed an increase of 34.8%) the number of immunoglobulin A, which however does not reach the level of healthy people and reducing the number of circulating complexes by 13.8%, which also indicates the normalization of this index. The first group – a significant improvement of immunological parameters increase of 3 indicators (CD4, CD8, CD4/CD8) and a decrease in the CIK. Analysis of changes in indicators Hamilton Rating Scale for Depression, also notes a reduction in the symptoms scores.

Disclosure of interest

The authors have not supplied their declaration of competing interest.