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Neuropsychological functioning in adolescents with first episode psychosis: A two-year follow-up study

Published online by Cambridge University Press:  16 April 2020

M. Mayoral ,
A. Zabala ,
O. Robles ,
I. Bombín ,
P. Andrés ,
M. Parellada ,
D. Moreno ,
M. Graell ,
O. Medina  and
C. Arango
M. Mayoral
Affiliation:
Adolescent Unit, Department of Psychiatry, Hospital General Universitario Gregorio Marañón, C/ Ibiza 43, 28009Madrid, Spain Centro de Investigación Biomédica en Red de Salud Mental CIBERSAM, Spain
A. Zabala
Affiliation:
Adolescent Unit, Department of Psychiatry, Hospital General Universitario Gregorio Marañón, C/ Ibiza 43, 28009Madrid, Spain Centro de Investigación Biomédica en Red de Salud Mental CIBERSAM, Spain
O. Robles
Affiliation:
Adolescent Unit, Department of Psychiatry, Hospital General Universitario Gregorio Marañón, C/ Ibiza 43, 28009Madrid, Spain Centro de Investigación Biomédica en Red de Salud Mental CIBERSAM, Spain
I. Bombín
Affiliation:
Adolescent Unit, Department of Psychiatry, Hospital General Universitario Gregorio Marañón, C/ Ibiza 43, 28009Madrid, Spain Centro de Investigación Biomédica en Red de Salud Mental CIBERSAM, Spain
P. Andrés
Affiliation:
Section of Psychiatry and Psychology, Hospital Infantil Universitario Niño Jesus, Avda/ Menéndez Pelayo 65, 28009Madrid, Spain
M. Parellada
Affiliation:
Adolescent Unit, Department of Psychiatry, Hospital General Universitario Gregorio Marañón, C/ Ibiza 43, 28009Madrid, Spain Centro de Investigación Biomédica en Red de Salud Mental CIBERSAM, Spain
D. Moreno
Affiliation:
Adolescent Unit, Department of Psychiatry, Hospital General Universitario Gregorio Marañón, C/ Ibiza 43, 28009Madrid, Spain Centro de Investigación Biomédica en Red de Salud Mental CIBERSAM, Spain
M. Graell
Affiliation:
Section of Psychiatry and Psychology, Hospital Infantil Universitario Niño Jesus, Avda/ Menéndez Pelayo 65, 28009Madrid, Spain
O. Medina
Affiliation:
Adolescent Unit, Department of Psychiatry, Hospital General Universitario Gregorio Marañón, C/ Ibiza 43, 28009Madrid, Spain Centro de Investigación Biomédica en Red de Salud Mental CIBERSAM, Spain
C. Arango*
Affiliation:
Adolescent Unit, Department of Psychiatry, Hospital General Universitario Gregorio Marañón, C/ Ibiza 43, 28009Madrid, Spain Centro de Investigación Biomédica en Red de Salud Mental CIBERSAM, Spain
*
*Corresponding author. Adolescent Unit, Department of Psychiatry, Hospital General Universitario Gregorio Marañón, C/ Ibiza 43, 28009 Madrid, Spain. Tel.: +34 91 586 8133; fax: +34 91 426 5005. E-mail address: [email protected] (C. Arango).
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Abstract

Cognitive deficits are a core feature of psychotic disorders. Both in adult and adolescent populations, studies have shown that patients with psychosis have poorer cognitive functioning than controls. The cognitive domains that seem to be affected are mainly attention, working memory, learning and memory, and executive function. However, with regard to the trajectory of cognitive function throughout the illness, there is still a dearth of prospective data in patients who develop psychosis during adolescence. In this article, neuropsychological functioning was assessed in a sample of 24 first episodes of early onset psychosis (EOP) and 29 healthy adolescents at baseline and after a two-year follow-up. Patients with EOP showed lower scores than controls in overall cognitive functioning and in all specific domains assessed (attention, working memory, executive function, and learning and memory) both at baseline and the two-year follow-up. When changes in cognitive functioning over two years were assessed, patients and controls showed significant improvement in almost all cognitive domains. However, this improvement disappeared in the patient group after controlling for improvement in symptomatology. Our findings support a neurodevelopmental pathological process in this sample of adolescents with psychosis.

Keywords

Early onset psychosisNeuropsychological abnormalitiesDevelopment
Type
Original article
Information
European Psychiatry , Volume 23 , Issue 5 , August 2008 , pp. 375 - 383
Copyright
Copyright © Elsevier Masson SAS 2008

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Footnotes

1

Tel.: +34 91 503 925. Fax: +34 91 574 4669.

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