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Neuropsychological function in subjects with psychotic and affective disorders. Relationship to diagnostic category and duration of illness

Published online by Cambridge University Press:  16 April 2020

H. Verdoux  and
F. Liraud
H. Verdoux
Affiliation:
Department of Psychiatry, University Victor Segalen Bordeaux 2, Hôpital Charles Perrens, 121 rue de la Béchade,33076Bordeaux cedex, France
F. Liraud*
Affiliation:
Department of Psychiatry, University Victor Segalen Bordeaux 2, Hôpital Charles Perrens, 121 rue de la Béchade,33076Bordeaux cedex, France
*
*Correspondence and reprints: Hélène Verdoux, CH Charles Perrens, Centre Carreire, 121 rue de la Béchade, 33076 Bordeaux cedex, France
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Summary

Objective

To explore the links between neuropsychological performance, diagnostic category and duration of illness in subjects with psychotic and affective disorders.

Methods

Memory and executive abilities were tested in consecutively admitted patients with schizophrenia (N = 20), other non-schizophrenic psychotic disorders (N = 29), bipolar disorder (N = 33) and major depression (N = 19).

Results

Subjects with schizophrenia had poorer global memory performances than subjects with major depression, and poorer delayed verbal memory abilities than those from the other three diagnostic groups. Executive abilities explored by the Stroop test and the Wisconsin Card Sorting Test did not differ between diagnostic groups. Neuropsychological performances were not influenced by previous duration of illness.

Conclusions

Memory deficits are the most discriminatory cognitive features between subjects with schizophrenia and those with other psychotic or mood disorders. The fact that cognitive deficits are static whatever the diagnostic group indirectly suggests that they may have a neurodevelopmental origin in subjects with schizophrenia, but perhaps also in subjects with other psychotic and mood disorders.

Keywords

affective disorderduration of illnessneuropsychological performancepsychotic disorder
Type
Original article
Information
European Psychiatry , Volume 15 , Issue 4 , June 2000 , pp. 236 - 243
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS 2000

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References

Albus, M., Hubmann, W., Wahleim, C., Sobizack, N., Mohr, F.Contrasts in neuropsychological profile between patients with first-episode schizophrenia and first-episode affective disorders Acta Psychiatr Scand 94 1996 93–97CrossRefGoogle ScholarPubMed
American Psychiatric Association DSM-IV. Diagnostic and statistical manual of mental disorders 4th ed., revWashington, DCAPA 1994Google Scholar
Beatty, W.W., Jocic, Z., Monson, N., Staton, R.D.Memory and frontal lobe dysfunction in schizophrenia and schizoaffective disorder J Nerv Ment Dis 181 1993 448–453CrossRefGoogle ScholarPubMed
Bilder, R.M., Lipschutz-Broch, L., Reiter, G., Geisler, S.H., Mayerhoff, D.I., Lieberman, J.A.Intellectual deficits in first-episode schizophrenia: evidence for progressive deterioration Schizophr Bull 18 1992 437–448CrossRefGoogle ScholarPubMed
Censits, D.M., Ragland, J.D., Gur, R.C., Gur, R.E.Neuropsychological evidence supporting a neurodevelopmental model of schizophrenia: a longitudinal study Schizophr Res 24 1997 289–298CrossRefGoogle ScholarPubMed
Cuesta, M.J., Peralta, V., Zarzuela, A.Illness duration and neuropsychological impairments in schizophrenia Schizophr Res 33 1998 141–150Google Scholar
David, A.S., Malmberg, A., Brandt, L., Allebeck, P., Lewis, G.IQ and risk for schizophrenia: a population-based cohort study Psychol M 27 1997 1311–1323CrossRefGoogle ScholarPubMed
Goldberg, T.E., Gold, J.M., Greenberg, R., Griffin, S., Schultz, C., Pickar, D. et al. Contrasts between patients with affective disorders and patients with schizophrenia on a neuropsychological test battery Am J Psychiatry 150 1993 1355–1362Google ScholarPubMed
Gruzelier, J., Seymour, L., Wilson, L., Jolley, A., Hirsch, S.Impairments on neuropsychological tests of temporohippocampal and frontohippocampal functions and word fluency in remitting schizophrenia and affective disorders Arch Gen Psychiatry 45 1988 623–629CrossRefGoogle ScholarPubMed
Jones, P., Rodgers, B., Murray, R., Marmot, M.Child developmental risk factors for adult schizophrenia in the British 1946 birth cohort Lancet 344 1994 1398–1402CrossRefGoogle ScholarPubMed
Jones, P., Done, J.From birth to onset: a developmental perspective of schizophrenia in two national births cohortsKevasha, M.S, Murray, R.MNeurodevelopment and adult psychopathology CambridgeCambridge University Press 1997 119–136Google Scholar
Hall, W., Farrell, M.Comorbidity of mental disorders with substance misuse Brit J Psychiatry 171 1997 4–5CrossRefGoogle ScholarPubMed
Harvey, P.D., Powchik, P., Parrella, M., White, L., Davidson, M.Symptom severity and cognitive impairment in chronically hospitalised geriatric patients with affective disorders Brit J Psychiatry 170 1997 369–374Google ScholarPubMed
Harvey, P.D., Silverman, J.M., Mohs, R.C., Parrella, M., White, L., Powchik, P. et al. Cognitive decline in late-life schizophrenia: a longitudinal study of geriatric chronically hospitalized patients Biol Psychiatry 45 1999 32–40CrossRefGoogle ScholarPubMed
Heaton, R.K.The Wisconsin Card Sorting Test (Manual) Odessa, FLPsychological Assessment Resources 1981Google Scholar
Heaton, R., Paulsen, J.S., McAdams, L.A., Kuck, J., Zisook, S., Braff, D. et al. Neuropsychological deficits in schizophrenics. Relationship to age, chronicity and dementia Arch Gen Psychiatry 51 1994 469–476CrossRefGoogle ScholarPubMed
Hoff, A.L., Shukal, S., Aronson, T., Cook, B., Ollo, C., Baruch, S. et al. Failure to differentiate bipolar disorder from schizophrenia on measures of neuropsychological function Schizophr Res 3 1990 253–260CrossRefGoogle ScholarPubMed
Hoff, A.L., Riordan, H., O'Donnell, D.W., Morris, L., De Lisi, L.E.Neuropsychological functioning of first-episode schizophreniform patients Am J Psychiatry 149 1992 898–903Google ScholarPubMed
Hyde, T.M., Nawroz, S., Goldberg, T.E., Bigelow, L.B., Strong, D., Ostrem, J.L. et al. Is there a cognitive decline in schizophrenia? A cross-sectional study Brit J Psychiatry 164 1994 494–500CrossRefGoogle Scholar
Isohanni, I., Järvelin, M.R., Nieminen, P., Jones, P., Rantakallio, P., Jokelainen, J. et al. School performance as a predictor of psychiatric hospitalization in adult life. A 28-year follow-up in the Northern Finland 1966 birth cohort Psychol M 28 1998 967–974CrossRefGoogle ScholarPubMed
Lafont, V., Medecin, I., Robert, P.h, Beaulieu, F.E., Kazes, M., Danion, J.M. et al. Initiation and supervisory processes in schizophrenia and depression Schizophr Res 34 1998 49–57CrossRefGoogle ScholarPubMed
Lecrubier, Y., Seehan, D.V., Weiller, E., Amorin, P., Bonora, I., Seehan, K.H. et al. The Mini International Neuropsychiatric Interview (MINI). A short diagnostic structured interview: reliability and validity according to the CIDI Eur Psychiatry 12 1997 224–231CrossRefGoogle Scholar
Liraud, F., Verdoux, H.Which temperamental characteristics are associated with substance use in subjects with psychotic and mood disorders? Psychiatr Res 93 2000 63–72CrossRefGoogle ScholarPubMed
Murray, R.M.Neurodevelopmental schizophrenia: the rediscovery of dementia praecox Br J Psychiatry 165 Suppl 25 1994 6–12CrossRefGoogle Scholar
McGrath, J., Scheldt, S., Welham, J., Clair, A.Performance on tests sensitive to impaired executive ability in schizophrenia, mania, and well controls: acute and subacute phases Schizophr Res 26 1997 127–137CrossRefGoogle ScholarPubMed
Mockler, D., Riordan, J., Sharma, T.Memory and intellectual deficits do not decline with age in schizophrenia Schizophr Res 26 1997 1–7CrossRefGoogle ScholarPubMed
Morice, R.Cognitive in flexibility and pre-frontal dysfunction in schizophrenia and mania Brit J Psychiatry 157 1990 50–54CrossRefGoogle Scholar
Nopoulos, P., Fleshman, L., Flaum, M., Ardnt, S., Andreasen, N.Stability of cognitive functioning early in the course of schizophrenia Schizophr Res 14 1994 29–37CrossRefGoogle ScholarPubMed
Ram, R., Bromet, E.J., Eaton, W.W., Pato, C., Schwartz, J.E.The natural course of schizophrenia: a review of first-admission studies Schizophr Bull 18 1992 185–207CrossRefGoogle ScholarPubMed
Russel, A.J., Munro, J.C., Jones, P.B., Hemsley, D.R., Murray, R.M.Schizophrenia and the myths of intellectual decline Am J Psychiatry 154 1997 635–639Google Scholar
Saykin, A.J., Gur, R.C., Gur, R.E., Mozley, P.D., Mozley, L.H., Resnick, S.M. et al. Neuropsychological function in schizophrenia. Selective impairment in memory and learning Arch. Gen. Psychiatry 48 1991 618–624CrossRefGoogle ScholarPubMed
Saykin, A.J., Shtasel, D.L., Gur, R.E., Kester, D.B., Mozley, L.H., Stafiniak, P. et al. Neuropsychological deficits in neuroleptic naive patients with first-episode schizophrenia Arch Gen Psychiatry 51 1994 124–131CrossRefGoogle ScholarPubMed
Signoret, J.L.BEM-84, Batterie d'efficience mnésique réduite ParisEditions Elsevier 1991Google Scholar
STATA Corporation STATA Statistical Software: Research 4.0 College station, TXSTATA Corporation 1995Google Scholar
Stroop, J.R.Studies of interference in serial verbal reactions J Exp Psychol 1 1935 643–661CrossRefGoogle Scholar
Strauss, M.E., Reynolds, K.S., Jayaram, G., Tune, L.E.Effects of anticholinergic medication on memory in schizophrenia Schizophr Res 3 1990 127–129CrossRefGoogle Scholar
Tham, A., Engelbrektson, K., Math, A.A., Johnson, L., Olsson, E., Åsberg-Wisted, A.Impaired neuropsychological performance in euthymic patients with recurring mood disorders J Clin Psychiatry 58 1997 26–29CrossRefGoogle ScholarPubMed
Van Gorp, W.G., Altshuler, L., Theberge, D.C., Wilkins, J., Dixon, W.Cognitive impairment in euthymic bipolar patients with and without prior alcohol dependence Arch Gen Psychiatry 55 1998 41–46CrossRefGoogle ScholarPubMed
Van, O.sJ., Jones, P., Lewis, G., Murray, R.Identical developmental precursors of chronic affective illness and schizophrenia in the 1946 British birth cohort Arch Gen Psychiatry 54 1997 625–631Google Scholar
Verdoux, H., Magnin, E., Bourgeois, M.Neuroleptic effects on neuropsychological test performance in schizophrenia Schizophr Res 14 1995 133–139CrossRefGoogle Scholar
Verdoux, H., Bergey, C., Assens, F., Abalan, F., Gonzales, B., Pauillac, P. et al. Prediction of duration of psychosis before first admission Eur Psychiatry 13 1998 346–352CrossRefGoogle ScholarPubMed
Verdoux, H., Liraud, F., Gonzales, B., Assens, F., Abalan, F., Beaussier, J.P. et al. Associations between neuropsychological performances and clinical variables in first-admitted subjects with psychotic disorders Schizophr Res 37 1999 197–203Google Scholar
Waddington, J.L., Youssef, H.A.Cognitive dysfunction in chronic schizophrenia followed prospectively over 10 years and its longitudinal relationship to the emergence of tardive dyskinesia Psychol M 26 1996 681–688CrossRefGoogle ScholarPubMed
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