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Neuroprotection in the Aftermath of a First Episode of Mania.

Published online by Cambridge University Press:  15 April 2020

M. Berk ,
R. Daglas ,
M. Yucel ,
O. Dandash  and
S.M. Cotton
M. Berk
Affiliation:
School of Medicine IMPACT Strategic Research Centre, Deakin University and University of Melbourne, Geelong, Australia
R. Daglas
Affiliation:
Orygen Youth Health Research Centre, University of Melbourne, Melbourne, Australia
M. Yucel
Affiliation:
Orygen Youth Health Research Centre, Monash University, Melbourne, Australia
O. Dandash
Affiliation:
Orygen Youth Health Research Centre, Monash University, Melbourne, Australia
S.M. Cotton
Affiliation:
Orygen Youth Health Research Centre, University of Melbourne, Melbourne, Australia

Abstract

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Objectives

Despite cognition being normal or even superior tocontrols prior to a first episode of mania, there is a decline in cognitivecapacity that is arguably steepest in the interval after a first episode ofmania. What is unclear, is the extent to which this can be prevented and whichagents might be most useful for doing so.

Methods

This study reports the outcomes of a single-blind, randomised control trial of maintenance therapy with lithium compared toquetiapine after a first episode of mania. Cognition and structural imagingwere the primary endpoints.

Results

This study examined a number of paper and pencil tests ofneurocognition as well as a computerised battery including Cogstate andPresentation. Tests used include the Wechsler Test of Adult Reading, the WechslerAbbreviated Scale of Intelligence, Digit Span and Digit Symbol sub-tests of the Wechsler Adult Intelligence Scale – III, Trail Making Test, Rey Auditory VerbalLearning Test, Controlled Oral Word Association Task, Attention Network Test, Go-Nogoand Stroop Tasks. Results of this study will be presented.

Conclusions

Given that cognition is a major symptomatic domain ofbipolar disorder and has substantive effects on quality of life, functioningand symptomatic outcomes, the ability to influence the trajectory of cognitivechange is of considerable clinical importance.

Type
Article: 0085
Information
European Psychiatry , Volume 30 , Issue S1: Abstracts of the 23rd European Congress of Psychiatry , March 2015 , pp. 1
Copyright
Copyright © European Psychiatric Association 2015
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