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Neuroleptic-induced extrapyramidal symptoms are accompanied by cognitive dysfunction in schizophrenia

Published online by Cambridge University Press:  16 April 2020

M. Krausz ,
S.H. Moritz ,
D. Naber ,
M. Lambert  and
B. Andresen
M. Krausz
Affiliation:
Universitäts-Krankenhaus Hamburg—Eppendorf, Klinik für Psychiatrie und Psychotherapie, Martinistrae 52, 20246Hamburg, Germany
S.H. Moritz
Affiliation:
Universitäts-Krankenhaus Hamburg—Eppendorf, Klinik für Psychiatrie und Psychotherapie, Martinistrae 52, 20246Hamburg, Germany
D. Naber
Affiliation:
Universitäts-Krankenhaus Hamburg—Eppendorf, Klinik für Psychiatrie und Psychotherapie, Martinistrae 52, 20246Hamburg, Germany
M. Lambert
Affiliation:
Universitäts-Krankenhaus Hamburg—Eppendorf, Klinik für Psychiatrie und Psychotherapie, Martinistrae 52, 20246Hamburg, Germany
B. Andresen
Affiliation:
Universitäts-Krankenhaus Hamburg—Eppendorf, Klinik für Psychiatrie und Psychotherapie, Martinistrae 52, 20246Hamburg, Germany
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Summary

Cognitive impairments in schizophrenics have been found to precede tardive dyskinesia and to co-exist with other motor deficits. However, little is yet known about the prevalence of cognitive disturbances in patients with neuroleptic-induced parkinsonism. From the literature on idiopathic parkinson, it was inferred that extrapyramidal symptoms (EPS) are accompanied by cognitive dysfunction. 85 schizophrenic in-patients were divided into EPS high and low scorers according to an established criterion (Simpson Angus Scale, cut-off score: 0.4). Cognitive impairments were assessed using a self-rating instrument measuring disturbances of information processing.

Patients with high EPS exhibited significantly elevated scores in six of ten cognitive and perceptual subscales (t = 2.1—3.1) as compared to low EPS patients. It is concluded that high EPS patients suffer from cognitive disturbances which are assumed to possess high relevance for both psycho-social and medical treatment. Cognitive problems may, when not considered, disturb compliance, insight of illness and transfer of learnt skills into everyday life.

Keywords

cognitionextrapyramidal symptomsneuropsychologyside-effects
Type
Original articles
Information
European Psychiatry , Volume 14 , Issue 2 , April 1999 , pp. 84 - 88
Copyright
Copyright © Elsevier, Paris 1999

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