Neuroimaging correlates of suicidal behavior in dementia

Abstract

Introduction

At pathomorphological research of suicides reveal neurogenerative changes, which determines the relevance of the search for neuroimaging predictors (suicidal behavior) SB in dementia.

Objectives

To study predictors of SB (in dementia, due to Alzheimer’s disease (AD), vascular (VD), mixed (MD) based on neuroimaging research.

Methods

We examined 213 patients with dementia in АD, VD, MD on a CT, which were divided by the factor of the presence of SB into the main and control groups.

Results

At patients with SB at AD expansion of basal cistern is revealed of the brain (59%), but signs of chronic ischemia in the form of a decrease in the density of brain matter in the projection of the basal ganglia and white matter (67%), dilation of the ventricular system of the brain (51%), more typical for patients without SB. At VD with SB periventricular leukoareosis (67%), expansion of subarachnoid spaces (82%) and deepening of cracks of a brain (67%) are found. Patients without SB were characterized by a decrease in the density of brain matter in the projection of the white matter (73%). At MD with SB expansion of subarachnoid spaces (100%), basal cistern of a brain (87%), periventricular leukoareosis (87%), decrease in density of substance in the brain were registered in the projection of the basal ganglia (100%). Patients without SB with MD had deepening of the brain slits (40%).

Conclusions

Neuroimaging signs in the form of chronic ischemia and pronounced atrophic changes in the brain are factors in the anti-risk of SB in dementia.

Disclosure

No significant relationships.