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Neurocognitive function in patients with negative thought disorders

Published online by Cambridge University Press:  13 August 2021

I. Fateev ,
M. Omelchenko  and
I. Pluzhnikov
I. Fateev
Affiliation:
Department Of Youth Psychiatry, The Mental Health Research Center, Moscow, Russian Federation
M. Omelchenko
Affiliation:
Department Of Youth Psychiatry, The Mental Health Research Center, Moscow, Russian Federation
I. Pluzhnikov*
Affiliation:
Department Of Youth Psychiatry, The Mental Health Research Center, Moscow, Russian Federation Department Of Adult Neuropsychology And Abnormal Psychology, Moscow Institute of Psychoanalysis, Moscow, Russian Federation
*
*Corresponding author.

Abstract

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Introduction

Negative thought disorders are found in various diagnoses in clinical practice. These symptoms may show a possible psychosis continuum and may be taken into account when assessing schizophrenic risk. Neurocognitive functioning of patients with negative thought disorders need to be clarified.

Objectives

Aim of the study is to identify and validate the differences of executive functions between patients with negative thought disorders and patients without thought disorders.

Methods

Used a standardized neuropsychological test battery. There were 15 patients with negative thought disorders (affective disorders, personality disorders, schizophrenic spectrum disorders) and 18 patients with depressive episode without thought disorders in the research. Patients aged 17-25 years. The Mann–Whitney U test and ANOVA were used for statistical analysis.

Results

Significant results were obtained from The Verbal Fluency Test, The Design Fluency Test, The Digit span, The Rey-Osterrieth Complex Figure and Bidstrup’s drawings (All tests have p-values less than 0.05). In the methods listed above, the results in the group of patients with negative thought disorders are significantly lower than in the group of patients without thought disorders.

Conclusions

The data indicate a violation of Executive functions among patients with negative thought disorders: inhibitory control, planning and regulation, working memory, difficulty switching, which related to left frontal lobe dysfunction. A lack of simultaneity and understanding figurative language, which is associated with right hemisphere dysfunction.

Disclosure

The reported study was funded by RFBR, project number 20-013-00772

Keywords

Schizophrenic spectrum disorderNeurocognitive functionExecutive functionsNegative thought disorders
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S794
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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