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Neurocognitive function in patients at high risk of schizophrenia with positive thought disorders

Published online by Cambridge University Press:  13 August 2021

I. Fateev ,
M. Omelchenko  and
I. Pluzhnikov
I. Fateev
Affiliation:
Department Of Youth Psychiatry, The Mental Health Research Center, Moscow, Russian Federation
M. Omelchenko
Affiliation:
Department Of Youth Psychiatry, The Mental Health Research Center, Moscow, Russian Federation
I. Pluzhnikov*
Affiliation:
Department Of Youth Psychiatry, The Mental Health Research Center, Moscow, Russian Federation Department Of Adult Neuropsychology And Abnormal Psychology, Moscow Institute of Psychoanalysis, Moscow, Russian Federation
*
*Corresponding author.

Abstract

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Introduction

The course of affective disorders varies significantly in clinical practice. There are many symptoms that are not related to affective disorders that cannot be described in other nosologies. In the present study such pathopsychological phenomena similar to psychotic symptoms and related to symptoms of “schizophrenia risk” were designated as positive thought disorders (PTD). These symptoms are understood as manifestations of delusional and hallucinatory register.

Objectives

Aim of the study is to identify and validate the differences of neurocognitive functions among patients with positive thought disorders and at high risk of schizophrenia and patients without thought disorders.

Methods

In the research there were 17 patients with high risk of schizophrenia dominated by PTD (affective disorders, personality disorders, schizophrenic spectrum disorders) and 18 patients without thought disorders (affective disorders, personality disorders) in the research. Patients aged 17-25 years.

Results

According to the results of the The Complex Figure test, the group with a high risk of schizophrenia had significantly low results on the “simultaneity” scale and points for copying the figure (p-value 0.04 and p-value 0.03). According to the results of the Verbal fluency test, the main group had significantly lower indices on the “loss of instruction” scale and on the number of repetitions (p-value 0.021 and p-value 0.009).

Conclusions

In the group of patients with a high risk of schizophrenia with positive thought disorders there are neurocognitive features in the form of reduced inhibitory control and a lack of simultaneity. The most sensitive methods are the Complex figure test and Verbal fluency Test.

Conflict of interest

The reported study was funded by RFBR, project number 20-013-00772

Keywords

Positive thought disorderhigh risk of schizophreniaNeurocognitive functioninhibitory control
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S525
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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