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Neurochemical markers for aggression-related personality traits

Published online by Cambridge University Press:  16 April 2020

R. Anckarsater ,
A. Forsman ,
K. Blennow  and
H. Anckarsater
R. Anckarsater
Affiliation:
Kungalv Hospital, Kungalv, Sweden
A. Forsman
Affiliation:
Department of Forensic Psychiatry Goteborg University, Goteborg, Sweden
K. Blennow
Affiliation:
Department of Neurochemistry Goteborg University, Goteborg, Sweden
H. Anckarsater
Affiliation:
Forensic Psychiatry Clinic, Malmo University Hospital, Malmo, Sweden

Abstract

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Background:

Various biological risk factors for aggressive behaviours have been proposed, including disturbances in monoaminergic neurotransmission, endocrine axes and central nervous system (CNS) integrity.

Aims:

To describe findings of correlations between markers of CNS chemical integrity, neurotransmission and hormone metabolism in relation to personality traits from forensic psychiatric investigees and normal subjects in a stress paradigm.

Method:

Cerebrospinal fluid (CSF) and serum (S) samples from 46 forensic psychiatric investigees and 35 healthy subjects undergoing knee replacement surgery were analysed in relation to aggressive personality traits as rated by the Karolinska Scales of Personality, the Psychoapthy Checklist-Revised and the Temperament and Character Inventory.

Results:

Aggressive traits were especially associated with increased HVA/5-HIAA ratios, indicating a deficient serotonergic tonic regulation of the monoaminergic activity, and with indices of deficient CNS integrity, such as increased CSF/S albumin ratios.

Conclusion:

Neurobiological vulnerability factors are associated with aggressive behavioural and personality traits.

Type
Poster Session 2: Biological Markers And Brain Imaging
Information
European Psychiatry , Volume 22 , Issue S1: 15th AEP Congress - Abstract book - 15th AEP Congress , March 2007 , pp. S317
Copyright
Copyright © European Psychiatric Association 2007
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