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Neurobiological and Clinical Predictors of Impulsivity in Bulimia Nervosa [PW09-03]

Published online by Cambridge University Press:  16 April 2020

F.J. Vaz Leal ,
L. Rodríguez Santos ,
M.I. Ramos Fuentes ,
M.J. Cardoso Moreno  and
N. Fernández Sánchez
F.J. Vaz Leal
Affiliation:
Psychiatry, Extremadura University, Badajoz, Spain
L. Rodríguez Santos
Affiliation:
Psychiatry, Extremadura University, Badajoz, Spain
M.I. Ramos Fuentes
Affiliation:
Psychiatry, Extremadura University, Badajoz, Spain
M.J. Cardoso Moreno
Affiliation:
Psychiatry, Extremadura University, Badajoz, Spain
N. Fernández Sánchez
Affiliation:
Psychiatry, Extremadura University, Badajoz, Spain

Abstract

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Objective:

The main aim of this study was to analyze the association between a set of neurobiological/clinical factors and impulsivity in patients suffering from bulimia nervosa, as well as the capability of this factors to predict the severity of impulsivity.

Methods:

The Impulsive Behaviors Scale (IBS), the Diagnostic Interview for Bordeline Patients - Revised (DIB-R), the Beck Depression Inventory (BDI), the Millon Multiaxial Clinical Inventory (MMCI-II) and the Family Environment Scale (FES) were applied to 70 female patients with DSM-IV BN (purging subtype). Twenty-four hour urinary excretion of norepinephrine (NE), 3-methoxy-4-hydroxyphenylglycol (MHPG), serotonin (5-HT), 5-hydroxi-indol-acetic acid (5-HIAA), dopamine (DA), homovallinic acid (HVA), and morning serum cortisol levels before and after the administration of 1 mg of dexamethasone were determined.

Results:

Impulsivity was associated to lower levels of urinary 5-HT and 5-HIAA, borderline features, and lower family expressed emotion.

Conclusions:

The consideration of impulsivity as a core clinical feature in patients with bulimia nervosa could lead us to identify clinical subtypes of patients, with specific clinical profiles and specific treatment needs.

Type
PW09-03
Information
European Psychiatry , Volume 24 , Issue S1: 17th EPA Congress - Lisbon, Portugal, January 2009, Abstract book , January 2009 , 24-E381
Copyright
Copyright © European Psychiatric Association 2009
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