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Morphophenotypical patterns in patients with negative symptoms in schizophrenia

Published online by Cambridge University Press:  23 March 2020

E. Kornetova ,
A.V. Semke ,
A.N. Kornetov ,
E.G. Dmitrieva ,
V.V. Dubrovskaya  and
N.A. Bokhan
E. Kornetova
Affiliation:
Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Endogenous Disorders Department, Tomsk, Russia
A.V. Semke
Affiliation:
Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Administration, Tomsk, Russia
A.N. Kornetov
Affiliation:
Siberian State Medical University, Faculty of Behavioral Medicine, Department of Clinical Psychology and Psychotherapy, Tomsk, Russia
E.G. Dmitrieva
Affiliation:
Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Endogenous Disorders Department, Tomsk, Russia
V.V. Dubrovskaya
Affiliation:
Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Endogenous Disorders Department, Tomsk, Russia
N.A. Bokhan
Affiliation:
Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Administration, Tomsk, Russia

Abstract

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Introduction

Positive-negative dichotomy in course of schizophrenia leads to search for factors which could influence the formation of basic symptoms. The study of patients’ body types and morphological peculiarities according clinical feature of schizophrenia could find some influence factors. Body type and regional morphologic dysplasias (RMD) are basically morphophenotypical patterns available for routine examination in usual clinical psychiatric practice.

Aims

To reveal associations between body type, morphologic dysplasias and course of schizophrenia.

Methods

Anthropometric, somatoscopy examination of patients with schizophrenia with gradually progressive negative disorders: emotional, volition, thought disturbances, increasing autism and social isolation, stable anhedonia with motivation defect were conducted. The accounted morbidity of 168 patients from the whole group of individuals with schizophrenia was about 10% (128 [76%] males, 40 [23.8%] females). Clinical presentations of schizophrenia met the criteria of ICD-10. Anthropometric investigation was conducted with the help of Martin's anthropometer and major thickness compasses for recognition of body type. RMD was registered descriptively.

Results

It was shown that in patients with negative course of schizophrenia asthenic body type prevailed (60%) with the accumulation of RMD (94,4%) in comparison with healthy individuals (26.2%, P< 0.001). Among patients with positive symptoms of schizophrenia picnic body type prevailed (P < 0.001).

Conclusions

Asthenic body type, accumulation of multiple RMD is associated with the domination of negative symptoms and continuous course of schizophrenia. Results of the study indicate the need for a deeper study of this issue on constitutional approach.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster Viewing: Schizophrenia and other psychotic disorders
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. s818
Copyright
Copyright © European Psychiatric Association 2017
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