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Mnestic disorders in long-term high-dose diazepam abuse: a pilot study

Published online by Cambridge University Press:  16 April 2020

HG Weeß ,
R Steinberg  and
M Pritzel
HG Weeß
Affiliation:
Pfalzklinik Landeck, Weinstraβe 100, 76889 Klingenmünster
R Steinberg
Affiliation:
Pfalzklinik Landeck, Weinstraβe 100, 76889 Klingenmünster
M Pritzel
Affiliation:
Department of Psychology, University Koblenz-Landau Im Fort 7, 76829Landau, Germany
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Summary

Cognitive impairment in long-term high-dose diazepam abusers (dose > 30 mg diazepam/day; duration of abuse > 12 months) was examined by administering four memory-related tests and comparing the outcomes with those of matched controls. Deficits were found in spatial and visual learning, spatial and visual short-term memory (STM) as well as for spatial and visual long-term memory (LTM). As for verbal aspects of memory, solely the acquisition of novel verbal material (verbal learning) was impaired, Furthermore, deficits in a concentration task were observed. In chronic abuse the established memory deficits are similar to cognitive impairment after single doses. Relaxing or anxiety-reducing effects of diazepam were no longer present. The results of this experimental study demonstrate the risks of diazepam use beyond therapeutic range.

Keywords

benzodiazepinesdiazepammemorycognitionlong-term high-dose abuse
Type
Original article
Information
European Psychiatry , Volume 9 , Issue 5 , 1994 , pp. 254 - 259
Copyright
Copyright © Elsevier, Paris 1994

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References

Angus, WRRomney, DMThe effect of diazepam on patient’s memory. J Clin Psychopharmacol 1984;4:203-6CrossRefGoogle Scholar
Aranko, KMattila, MJSeppala, TDevelopment of tolerance and crosstolerance to the psychomotor actions of lorazepam and diazepam in man. Br J Clin Pharmacol 1983;15:545–52CrossRefGoogle Scholar
Brickenkamp, RTest d2: Aufmerksamkeit-belastungstest- Handanweisung Göttingen: Hogrefe, 1962Google Scholar
Broadbent, DEPerception and Communication Oxford: Pergamon Press, 1958CrossRefGoogle Scholar
Buschke, HAltman, PEvaluating storage, retention, and retrieval in disordered memory and learning. Neurology 1974;24:1019-25CrossRefGoogle ScholarPubMed
Curran, HVTranquillising memories: a review of the effects of BZD. Biol Psychol 1986:6,23(2): 180–213CrossRefGoogle Scholar
Curran, HVBenzodiazepines, memory and mood: a review. Psychopharmacology 1991;105:1–8CrossRefGoogle ScholarPubMed
DSM, III-RDiagnostische Kriterien und Differentialduignosen des Diagnostischen und Statistischen Manuals psychischer Störungen DSM III-R Weinheim: Beltz-Verlag, 1989Google Scholar
Dundee, JWLilburn, JKNair, SKGeorge, KAStudies of drugs given before anaesthesia. XXVI. Lorazepam. Br J Anaesthesia 1977;49:1047-56CrossRefGoogle ScholarPubMed
De Sousa, MRFiguiera, MLLoureiro, FHindmarch, LLorazepam and clobazam in anxious elderly patients. Clobazam: Royal Society of Medicine International Congress and symposium Series No 43, Academic Press and Royal Society of Medicine, 1981Google Scholar
File, SELister, RGDoes tolerance develop with once weekly dosing?. Br J Clin Pharmacol 1983;16:645-50CrossRefGoogle ScholarPubMed
George, KADundee, JWRelative amnestic actions of diazepam, flunitrazepam and lorazepam in man. Br J Clin Pharmacol 1977;16:45–50Google Scholar
Ghoneim, MMMewaldt, SPBerie, JLHinrichs, JVMemory and performance effects of single and 3 week administration of diazepam. Psychopharmacology 1981;73:147-51CrossRefGoogle ScholarPubMed
Ghoneim, MMMewaldt, SPHinrichs, JRDose response analysis of the behavioral effects of Diazepam: II. Psychomotor performance, cognition and mood. Psychopharmacology 1984;82:296–300CrossRefGoogle Scholar
Golombok, SCognitive impairment in long-term BZD users. Psychol Med 1988;18:365-74CrossRefGoogle Scholar
Grant, DBerg, EA behavioral analysis of degree of reinforcement and ease of shifting to new responses in a weigl-type card sorting problem. J Exp Psychol 1984:38:404-11CrossRefGoogle Scholar
Hamilton, MHamilton Depression ScaleIn: Guy, W ed. ECDEU Assessment Manual for Psychopharmacology Rockville, Maryland: Rev Ed, 1976:179-92Google Scholar
Hippius, HEngel, RLaakman, GBenzodiazepine. Berlin: Springer-Verlag, 1986CrossRefGoogle Scholar
John, UVeltrup, CSchnofl, AWetterling, TKanitz, DDilling, HGedächtnisdefizite Alkoholabhängiger in den ersten Wochen der Abstinenz. Zeitschrift für Klinische Psychologie. Psychopathol Psychother 1991;39(4):348-56Google Scholar
Kimura, DRight temporal lobe damage. Arch Neurol 1963;8:264-71CrossRefGoogle ScholarPubMed
Kortilla, KLinnoila, MAmnestic action of and skills related to driving after intravenous flunitrazepam. Acta Anaesthesiol Stand 1976;20:160-8CrossRefGoogle Scholar
Kothary, SPBrown, ACDPandit, UASamra, SKPandit, MDTime and course of anti-recall effect of diazepam and lorazepam following oral administration. Anaesthesiol 1981;55:641-4CrossRefGoogle Scholar
Lehrl, SMehrfach-Wortschatz-Intelligenztest Erlangen: Dr med D Straube Verlag, 1977Google Scholar
Lillequist, RLinnoila, MMattila, MJEffects of diazepam and chlorpromazine on memory functions in man. Eur J Clin Pharmacol 1978;14:229-43Google Scholar
Linden, MKrautzig, EBefindlichkeitsmessung in kurzzeitigen Abständen: ein experimenteller Beitrag zur Validierung der Befindlichkeitsskala (Bf-S) nach von Zerssen. Pharmacopsychiatry 1981;14:40-1CrossRefGoogle Scholar
Lucki, IRickels, KGeller, MChronic use of BZD and psychomotor and cognitive test performance. Psychopharmacology 1986;88:426-33CrossRefGoogle Scholar
McKay, ACDundee, JWEffects of Benzodiazepines on memory. Br J Anaesthesia 1980;52:1247-57CrossRefGoogle ScholarPubMed
Roehrs, TZorick, FSicklesteel, JWittig, RHartse, KRoth, TEffects of hypnotics on memory. J Clin Psychopharmacol 1983;3:310-3CrossRefGoogle ScholarPubMed
Spielberger, CDGorsuch, RLushene, RESTAI. Manual for the State- Trait-Anxiety-Inventory Palo Alto, 1970Google Scholar
Steinberg, RSoyka, MProbleme der Benzodiazepin-Langzeitbehandlung. Schweiz Rund 1989;27/28:784-7Google Scholar
Steinberg, RBenzodiazepine - gute Schlafmittel?. Fortschr Med 1989:107,2:62Google Scholar
Taylor, JTinklenberg, JCognitive Impairment and BenzodiazepinesIn: Meltzer, ed. Psychopharmacology, The Third Generation in Progress. New York: Raven Press, 1987Google Scholar
Weeß, HGBirzele, JPritzel, MSteinberg, RMnestic disorders in longterm benzodiazepine medication. J Psychophysiol 1991;5:134Google Scholar
Weidlich, SLamberti, GDCS: Diagnostikum für Cerebralschädigung Bern: Huber-Verlag, 1980Google Scholar
Wittenborn, JRAssessment of the effects of drugs on memoryIn: Hindmarch, IOtt, H eds. Benzodiazepine Receptor Ligands, Memory and Information Processing 1988Google Scholar
Wolf, BBrenner, DRüther, EBenzodiazepine abuse and dependence in psychiatric inpatients. Psychopharmacol 1987;18:37-9CrossRefGoogle Scholar
Zerssen von, DDie Befindlitchkeitsskalen, Parallelformen Bf-S und Bf-S’ Weinheim: Beltz, 1976Google Scholar
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