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Method of treating alcohol dependence complicated by amnestic disorders

Published online by Cambridge University Press:  13 August 2021

I. Sosin ,
Y. Babenko ,
O. Honcharova ,
G. Mysko ,
O. Sergienko  and
I. Lisova
I. Sosin*
Affiliation:
Narcology Department, Kharkiv, Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine
Y. Babenko
Affiliation:
Narcology Department, Kharkiv, Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine
O. Honcharova
Affiliation:
Narcology Department, Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine
G. Mysko
Affiliation:
Narcology Department, Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine
O. Sergienko
Affiliation:
Narcology Department, Kharkiv, Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine
I. Lisova
Affiliation:
Narcology Department, Kharkiv, Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine
*
*Corresponding author.

Abstract

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Introduction

Amnesia and palimpsests occurring and recurring in alcohol addicts due to alcohol intoxication (Ebrietas alcoholica) are accompanied by hazardous memory failures, gradual mental degradation and psychoorganic syndrome, which evidences urgent clinical, therapeutic and therapeutic issue in addictology, psychiatry, forensic medicine, sociology, medical psychology, etc. At EPA initiative (2019), research interest in non-invasive brain stimulation tools and methods for such populations was activated.

Objectives

Development of a patentable method of treatment in addictology using pyracetam and nicotinic acid transcerebral electrophoresis (TCE).

Methods

Valid clinical-diagnostic, laboratory, biochemical, electrophysiological, psychological (scaling, testing), statistical methods for identification of alcohol dependence complicated by amnestic disorders.

Results

The method of treatment of alcohol dependence complicated by amnestic disorders (Patent 141785 UA) provides complex pharmacological and drug-free therapy. Antiamnesic drugs are administered by TCE bilaterally; pyracetam 20% solution to the left orbit through active negative electrodes, and nicotinic acid 0.1% solution to the right orbit (positive electrode in the occipital fossa), current of 2-4 mA, 20-30 minutes exposure. The procedure was performed daily with a TCE device, for a 10-day course of treatment along with psychotherapeutic potentiation. TCE provides the ionic implementation of pharmacological agents in the brain and their physiological electrical stimulation.

Conclusions

In a representative clinical trial, using statistical methods and generated bank of patient-specific observations, significant potentiating effects of combined drug-free, non-invasive transcerebral electrical stimulation and electrophoretic implementation of pyracetam and nicotinic acid were demonstrated.

Keywords

pharmacotherapyAlcohol addictionAmnestic disorders
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S563 - S564
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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