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Long-term treatment of chronic schizophrenia with risperidone: a study with plasma levels

Published online by Cambridge University Press:  16 April 2020

M.C. Mauri ,
V. Laini ,
L. Boscati ,
R. Rudelli ,
V. Salvi ,
R. Orlandi  and
P. Papa
M.C. Mauri*
Affiliation:
Department of Clinical Psychiatry, Clinical Neuropsychopharmacology Unit, University of Milan, IRCCS Ospedale Maggiore, Via F. Sforza35, 20122Milan, Italy
V. Laini
Affiliation:
Department of Clinical Psychiatry, Clinical Neuropsychopharmacology Unit, University of Milan, IRCCS Ospedale Maggiore, Via F. Sforza35, 20122Milan, Italy
L. Boscati
Affiliation:
Department of Clinical Psychiatry, Clinical Neuropsychopharmacology Unit, University of Milan, IRCCS Ospedale Maggiore, Via F. Sforza35, 20122Milan, Italy
R. Rudelli
Affiliation:
Department of Clinical Psychiatry, Clinical Neuropsychopharmacology Unit, University of Milan, IRCCS Ospedale Maggiore, Via F. Sforza35, 20122Milan, Italy
V. Salvi
Affiliation:
Department of Clinical Psychiatry, Clinical Neuropsychopharmacology Unit, University of Milan, IRCCS Ospedale Maggiore, Via F. Sforza35, 20122Milan, Italy
R. Orlandi
Affiliation:
Department of Toxicology, IRCCS Policlinico S. Matteo, Pavia, Italy
P. Papa
Affiliation:
Department of Toxicology, IRCCS Policlinico S. Matteo, Pavia, Italy
*
*Correspondence and reprints. E-mail address: [email protected] (M.C. Mauri).
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Abstract

Twenty-four chronic schizophrenic outpatients with a mean age of 37.21 years ± 9.96 SD were treated with risperidone (RSP) at the dosage of 2–9 mg/die (mean 4.46 mg/die ± 1.30 SD, mean 0.06 mg/kg ± 0.01 SD) for a year.

Clinical evaluation was assessed with the Brief Psychiatric Rating Scale (BPRS), Positive and Negative Symptoms Scale (PANSS), Extrapyramidal Side Effects Rating Scale (EPSE) and a checklist for Anticholinergic Side Effects (ACS) at T0, then after 1 (T1), 2 (T2), 3 (T3), 6 (T6), 9 (T9) and 12 (T12) months. RSP and 9-hydroxy-risperidone (9OH-RSP) plasma levels were determined at T12 by the HPLC method. BPRS and PANSS mean values showed a significant improvement during the study. No correlation between RSP dosage (mg/kg) and RSP, 9OH-RSP plasma levels or active moiety resulted. A positive correlation between age and active moiety was observed. A positive correlation between RSP and 9OH-RSP plasma levels was observed. A curvilinear relationship between active moiety and PANSS improvement (%) was observed. Patients with the higher PANSS amelioration showed RSP + 9OH-RSP plasma levels ranging from 15 to 30 ng/mL. RSP seems to be quite an effective drug. It seems, however, difficult to devise appropriate dose schedules and plasma level determination seems to be necessary in some cases.

Type
Original article
Information
European Psychiatry , Volume 16 , Issue 1 , February 2001 , pp. 57 - 63
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS.

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