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Long-term efficacy of tianeptine on alcoholic relapses in non-depressed alcoholic patients. Preliminary results

Published online by Cambridge University Press:  16 April 2020

JD Favre ,
H Lôo ,
C Marey  and
B Delalleau
JD Favre
Affiliation:
Hôpital Bégin, Service de Psychiatric, Saint Mandé
H Lôo
Affiliation:
Service Hospitalo-Universitaire de Santé mentale et de Thérapeutique, Hôpital Sainte Anne, Paris
C Marey
Affiliation:
Institut de Recherches Internationales Servier, 6, place des Pléades, 92415Courbevoie, France
B Delalleau*
Affiliation:
Institut de Recherches Internationales Servier, 6, place des Pléades, 92415Courbevoie, France
*
* Correspondence and reprints.
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Summary

Tianeptine, whose main neurochemical action is to increase 5-HT uptake, significantly decreased alcohol consumption in rats. During a tianeptine long-term treatment study, gamma-GT levels in depressed alcoholic patients decreased, suggesting that this medication could be useful in alcoholism. The role of tianeptine in the prevention of alcoholic relapses is being evaluated in a double-blind placebo-controlled study. Two hundred non-depressed patients satisfying DSM III-R criteria for Psychoactive Substance Dependence (alcohol – daily intake greater than 80 g) will enter the study after alcohol withdrawal. A minimum score of three on the Short-Mast Questionnaire, mean cell volume above 98 f1 and/or gamma-GT more than twice the upper normal value are required. Patients are treated as out-patients and surveyed for 9 months. The maintenance of abstinence is estimated through clinical and laboratory assessments. The alcohol intake is evaluated in patients who relapse. Efficacy is determined secondarily using Clinical Global Impressions Scale, Hopkins Symptom Check List and visual analogue scales. Somatic complaints are collected using AMDP-5. Preliminary results are presented.

Keywords

tianeptinealcoholismalcohol relapse and appetence
Type
Research Article
Information
European Psychiatry , Volume 8 , Issue S2: Neuroendocrinological aspects of depression 28 June 1992, Nice, France , 1993 , pp. 125s - 129s
Copyright
Copyright © Elsevier, Paris 1993

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References

American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised) (DSM III-R). APA, Washington, DCGoogle Scholar
Daoust, MCompagnon, PLegrand, EMocaër, E (1992) Tianeptine, a specific serotonin uptake enhancer, decreases ethanol intake in rats. Alcohol& Alcoholism 27, 1, 15–17Google ScholarPubMed
Derogatis, CRLipman, RSRickels, Ket al (1974) The Hopkins Symptom Checklist (HSCL): a self-report symptom inventory. Behav Sci 19, 1–15CrossRefGoogle ScholarPubMed
Favre, JDGillet, CJean, P (1991) Premières conclusions d'une recherche sur l'évaluation des soins donnés aux malades alcooliques. Psychiatrie Sociale à l'heure européenne. ERES, Toulouse. Collection ‘Psychiatrie et Societé, 363–373Google Scholar
Feighner, JPAden, GCFabre, LFet al (1983) Comparison of alprazolam, imipramine and placebo in the treatment of depression. JAMA 249, 3057–3064CrossRefGoogle ScholarPubMed
Guy, W (1976) ECDEU Assessment Manual for Psychopharmacology. Department of Health, Education and Welfare, Washington, DC, US, 217–222Google Scholar
Lôo, HMalka, RDefrance, RBarrucand, DBenard, JYNiox-Rivière, HRaab, ASarda, AVachonfrance, GKamoun, A (1988) Tianeptine and amitriptyline: controlled double-blind trial in depressed alcoholic patients. Neuropsychobiology 19, 79–85CrossRefGoogle ScholarPubMed
Malka, RLôo, HGanry, HMarey, CKamoun, A (1990) Acceptabilité clinique et paraclinique de la tianeptine prescrite au long cours chez des patients déprimés et alcooliques. Alcoologie 11, 3, 149–158Google Scholar
Malka, RLôo, HGanry, HSouche, AMarey, CKamoun, A (1992) Long-term administration of tianeptine in depressed patients after alcohol withdrawal. Br J Psychiatry 160(suppl 15), 66–71CrossRefGoogle Scholar
Mendels, JSchless, AP (1986) Comparative efficacy of alprazolam, imipramine and placebo administered once a day in treating depressed patients. J Clin Psychiatry 47, 357–361Google Scholar
Montgomery, SÅsberg, M (1979) A new depression scale designed to be sensitive to change. Br J Psychiatry 134,382–389CrossRefGoogle ScholarPubMed
Selzer, MLVinokur, Avan Rooijen, L (1975) A self-administered Short Michigan Alcoholism Screening Test (SMAST). J Stud Alcohol 36, 117–126CrossRefGoogle Scholar
Vaillant, GEClark, WCyrus, CMilofsky, ESKopp, JWells Wulsin, VMogielnicki, NP (1983) Prospective study of alcoholism treatment - eight-year follow-up. Am J Med 75, 455–462CrossRefGoogle ScholarPubMed
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