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Long-term consequences of chronic PTSD on quality of life, cardiovascular risk and stress hormones in aging former refugee children

Published online by Cambridge University Press:  16 April 2020

C. Muhtz ,
K. Godemann ,
C. von Alm ,
C. Wittekind ,
K. Wiedemann ,
A. Yassouridis  and
M. Kellner
C. Muhtz
Affiliation:
Psychiatry and Psychotherapy, University-Hospital Hamburg-Eppendorf, Hamburg, Germany
K. Godemann
Affiliation:
Psychiatry and Psychotherapy, University-Hospital Hamburg-Eppendorf, Hamburg, Germany
C. von Alm
Affiliation:
Psychiatry and Psychotherapy, University-Hospital Hamburg-Eppendorf, Hamburg, Germany
C. Wittekind
Affiliation:
Psychiatry and Psychotherapy, University-Hospital Hamburg-Eppendorf, Hamburg, Germany
K. Wiedemann
Affiliation:
Psychiatry and Psychotherapy, University-Hospital Hamburg-Eppendorf, Hamburg, Germany
A. Yassouridis
Affiliation:
Max Planck Institute of Psychiatry, Munich, Germany
M. Kellner
Affiliation:
Psychiatry and Psychotherapy, University-Hospital Hamburg-Eppendorf, Hamburg, Germany

Abstract

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Introduction

Several studies suggested that having a history of posttraumatic stress disorder (PTSD) is associated with higher rates of somatic morbidity and disease.

Aim

The aim of the present study was to investigate systematically the long-term-consequences of PTSD on cardiovascular risk, quality of life and stress hormones in a sample of former refugee children.

Methods

In 25 subjects with chronic PTSD and 25 trauma-controlled subjects we measured variables of the metabolic syndrome supplemented by the ankle-brachial index and h-CRP. Quality of life was assessed by the SF-36. Cortisol, ACTH, DHEA were measured in the low dose dexamethasone-suppression-test. Additionally, salivary cortisol was assessed at 0800, 1200, 1600 and 2200 hours.

Results

We found a significant group effect between participants with PTSD and without PTSD regarding quality of life, but not on any metabolic parameter including the ankle-brachial index or cortisol, ACTH and DHEA in plasma before and after dexamethasone or salivary cortisol.

Conclusion

Chronic PTSD was associated with diminished quality of life more than six decades after traumatization, but not with altered metabolic or endocrine variables. Nevertheless, search for subgroups of PTSD patients with childhood traumatization leading to different metabolic and endocrine long-term consequences in aging PTSD patients is needed.

Type
P02-479
Information
European Psychiatry , Volume 26 , Issue S2: Abstracts of the 19th European Congress of Psychiatry , March 2011 , pp. 1075
Copyright
Copyright © European Psychiatric Association 2011
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