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Lithium-induced Thyroid Dysfunction and the Duration of Lithium Treatment in Patients with Bipolar Disorder.
Published online by Cambridge University Press: 15 April 2020
Abstract
Negative impact of long-term lithium treatment on kidney and thyroid functions makes the important problem of such therapy. While kidney functions deteriorate in time-dependent manner after ten years of lithium therapy it is unclear whether a significant association exists between thyroid dysfunction and duration of lithium administration.
The aim was to compare thyroid hormones and antibodies in bipolar patients receiving lithium for 10-19 years with those receiving for 20 years or more.
The cross-sectional study was performed on 66 patients (21 male, 45 female) with bipolar mood disorder, receiving lithium for 10-44 (20+9) years. Thyroid stimulating hormone (TSH), free thyroxine (fT3) and free triiodothyronine (fT4) as well as thyroid peroxidase (TPO), thyroglobulin (TG) and TSH receptor (TSH-R) antibodies were measured.
Features of hypothyroidism were found in 10 (22%) female patients but not in male patients. A significant percentage of patients had abnormally high anti-TPO, and anti-TG antibodies (45% and 65%, respectively). There were no differences in thyroid function between 38 patients receiving lithium for 10-19 years and 28 patients taking the drug for 20 years or more.
The results confirm greater susceptibility of female bipolar patients for lithium-induced hypothyroidism. High anti-TPO and anti-TG antibodies suggest a possibility of autoimmune disturbance in these subjects. However, in contrast to lithium effect on kidney function, our results do not show an association between duration of long-term lithium therapy and thyroid dysfunction.
- Type
- Article: 0182
- Information
- European Psychiatry , Volume 30 , Issue S1: Abstracts of the 23rd European Congress of Psychiatry , March 2015 , pp. 1
- Copyright
- Copyright © European Psychiatric Association 2015
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