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Links between posterior pituitary activity, psychometric profile and other endocrine abnormalities in anorexia nervosa: a multimodal evaluation

Published online by Cambridge University Press:  01 September 2022

S. Doua ,
R. Jérôme ,
B. Traverse ,
M. Zennadi ,
C. Boutet ,
A. Hammour ,
N. Germain ,
C. Massoubre  and
B. Galusca
S. Doua*
Affiliation:
CHU Saint Etienne, Endocrinology, Saint Etienne, France
R. Jérôme
Affiliation:
CERMEP, Nuclear Medecine, Lyon, France
B. Traverse
Affiliation:
CHU Saint Etienne, Endocrinology, Saint Etienne, France
M. Zennadi
Affiliation:
CHU Saint Etienne, Endocrinology, Saint Etienne, France
C. Boutet
Affiliation:
CHU Saint Etienne, Radiology, Saint Etienne, France
A. Hammour
Affiliation:
CHU Saint Etienne, Endocrinology, Saint Etienne, France
N. Germain
Affiliation:
CHU Saint Etienne, Endocrinology, Saint Etienne, France
C. Massoubre
Affiliation:
CHU Saint Etienne, Psychiatry, Saint Etienne, France
B. Galusca
Affiliation:
CHU Saint Etienne, Endocrinology, Saint Etienne, France
*
*Corresponding author.

Abstract

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Introduction

Opioid system activity was found disturbed in several reward circuit areas in restrictive anorexia nervosa (AN) patients but also at the pituitary level. The role of this specific abnormality in AN physiopathology remains unknown.O

Objectives

We aimed to evaluate the relationship of upper mentioned AN abnormality with its classical pituitary features and eating behavior traits.

Methods

PET [11C] diprenorphin binding potential (BPND) were processed for each pituitary part in three groups of young women: 12 AN, 11 recovered AN patients (ANrec), and 12 Controls. Anterior pituitary hormones and neurohypophysis (NH) 12 points circadian profile including copeptin and oxytocin, psychological scores were evaluated in these subjects as well as in 13 bulimic (BN) patients.

Results

[11C] diprenorphin pituitary binding was found to be fully localized in NH. Only AN patients’ NH present lower [11C] diprenorphin BPND than Controls, interpreted as a higher opioid tone. Both AN and ANrec show lower copeptin/24h than in Controls but no difference in oxytocin. BN showed increased copeptin and low oxytocin. In AN patients copeptin inversely correlate with Restrained Eating while oxytocin correlate with the External Eating score. NH [11C] diprenorphin BPND correlated with leptin but not with copeptin or oxytocin.

Conclusions

Neurohypopysis opioid tone in anorexia nervosa seem not to impact the vasopressin or oxytocin release but still may interfere in gonadal axis regulation. Copeptin, a good indicator of hydration state, may be a good tool to detect hidden restrictive or purging behaviors. Specific correlates with AN psychologic features still suggest a physiopathological involvement.

Disclosure

No significant relationships.

Keywords

Anorexia nervosaCopeptinOxytocinCerebral opioid tone
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S148 - S149
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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