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Lack of association between cholesterol blood levels and platelet serotonin uptake

Published online by Cambridge University Press:  16 April 2020

I Modai ,
A Valevski ,
L Kikinzon ,
Z Jerushalmy  and
A Weizman
I Modai
Affiliation:
Gehah Psychiatric Hospital, PO Box 102, 49100Petah Tiqva Felsenstein Medical Research Center, Beilinson Medical Center, Petah Tiqva Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
A Valevski
Affiliation:
Gehah Psychiatric Hospital, PO Box 102, 49100Petah Tiqva Felsenstein Medical Research Center, Beilinson Medical Center, Petah Tiqva Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
L Kikinzon
Affiliation:
Gehah Psychiatric Hospital, PO Box 102, 49100Petah Tiqva
Z Jerushalmy
Affiliation:
Felsenstein Medical Research Center, Beilinson Medical Center, Petah Tiqva Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
A Weizman
Affiliation:
Gehah Psychiatric Hospital, PO Box 102, 49100Petah Tiqva Felsenstein Medical Research Center, Beilinson Medical Center, Petah Tiqva Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
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Summary

It has been suggested that low serum cholesterol interferes with brain serotonergic functioning, which results in increased suicidal and aggressive tendencies. To test this hypothesis we investigated the relationship between serum cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL) and triglyceride levels, and serotonin uptake by blood platelets in 17 healthy men aged 39.5 ± 10.2 years. Platelet serotonin uptake and serum lipids were assayed concomitantly for each individual. Serum cholesterol levels and other serum lipid levels did not correlate with serotonin uptake by platelets at the concentration of 2 × 10−5 M (a concentration within the maximal uptake capacity range). The results indicate no influence of cholesterol on serotonin uptake, as opposed to some investigators who suggested that high risk of suicide and aggressiveness in hypocholesterolemic individuals is related to impaired serotonin transport.

Keywords

cholesterolserotoninuptake
Type
Original article
Information
European Psychiatry , Volume 10 , Issue 7 , 1995 , pp. 352 - 354
Copyright
Copyright © Elsevier, Paris 1995

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