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Ketamine As A New Therapeutic Option For The Management Of Mental Disorders

Published online by Cambridge University Press:  01 September 2022

M. Turki ,
O. Abidi ,
S. Ellouze ,
R. Ben Jmeaa ,
J. Nasri ,
N. Halouani  and
J. Aloulou
M. Turki*
Affiliation:
Hedi Chaker University Hospital, Psychiatry “b” Department, Sfax, Tunisia
O. Abidi
Affiliation:
Hedi Chaker University Hospital, Psychiatry “b” Department, Sfax, Tunisia
S. Ellouze
Affiliation:
Hedi Chaker University Hospital, Psychiatry “b” Department, Sfax, Tunisia
R. Ben Jmeaa
Affiliation:
Hedi Chaker University Hospital, Psychiatry “b” Department, Sfax, Tunisia
J. Nasri
Affiliation:
Hedi Chaker University Hospital, Psychiatry “b” Department, Sfax, Tunisia
N. Halouani
Affiliation:
Hedi Chaker University Hospital, Psychiatry “b” Department, Sfax, Tunisia
J. Aloulou
Affiliation:
Hedi Chaker University Hospital, Psychiatry “b” Department, Sfax, Tunisia
*
*Corresponding author.

Abstract

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Introduction

Ketamine is routinely used for anesthetic induction because of its dissociative properties. Recently, it has attracted attention as a rapid-acting anti-depressant, but other studies have also reported its efficacy in the management of diverse psychiatric pathologies previously resistant to treatment.

Objectives

We aimed to review the efficacity of ketamine in the management of mental disorders.

Methods

We conducted a litterature review through pubmed database, using the following keywords: “mental illness”; “ketamine”;”depression”;”anxiety disorders”;”eating disorders”;”substance use disorders”.

Results

Ketamine has primarily been used in psychiatry for people with treatment-resistant depression. Its efficacy in reducing suicidal ideation has been previously reported. Furthermore, Ketamine may be a potential therapeutic option for patients with treatment-resistant anxiety disorders, especially obsessive compulsive disorder (OCD) and post-traumatic stress disorder. It has recently been reported a rapid onset anxiolytic activity in treatment-resistant social anxiety disorder and generalized anxiety disorder. Besides, Ketamine use in subjects suffering from eating disorders was associated with a complete remission of severe anorexia nervosa with a return to normal weight and a decrease in body preoccupations. The use of ketamine alone or in combination with other therapies was effective in reducing alcohol and substance use, prolonging abstinence, reducing craving and enhancing motivation. ketamine in combination with motivational enhancement therapy may be an effective pharmacotherapy for initiating and sustaining abstinence from alcoholics

Conclusions

ketamine shows great promise as a treatment for several mental disorders. However, its possible side effects and short duration of efficacy limit its use. Further studies exploring longer-term outcomes and administration protocols are needed.

Disclosure

No significant relationships.

Keywords

KetamineMental Disordersresistant
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S877 - S878
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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