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The inventory of depressive symptomatology is more sensitive to changes in depressive symptomatology than the hamilton depression rating scale in patients with minor depression

Published online by Cambridge University Press:  16 April 2020

I. Helmreich ,
S. Wagner ,
R. Mergl ,
A.-K. Allgaier ,
M. Hautzinger ,
V. Henkel ,
U. Hegerl  and
A. Tadić
I. Helmreich
Affiliation:
Department of Psychiatry and Psychotherapy, University Medical Centre Mainz, Mainz, Germany
S. Wagner
Affiliation:
Department of Psychiatry and Psychotherapy, University Medical Centre Mainz, Mainz, Germany
R. Mergl
Affiliation:
Department of Psychiatry, University of Leipzig, Leipzig, Germany
A.-K. Allgaier
Affiliation:
Department of Child and Adolescent Psychiatry, Ludwig-Maximilians-University Munich, Munich, Germany
M. Hautzinger
Affiliation:
Institute of Psychology, Department of Clinical and Developmental Psychology, University of Tübingen, Tübingen, Germany
V. Henkel
Affiliation:
Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany
U. Hegerl
Affiliation:
Department of Psychiatry, University of Leipzig, Leipzig, Germany
A. Tadić
Affiliation:
Department of Psychiatry and Psychotherapy, University Medical Centre Mainz, Mainz, Germany

Abstract

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Background

Depression rating scales play a decisive role in the assessment of the severity of depression and the evaluation of the efficacy of antidepressant treatments. The Hamilton Depression Rating Scale (HAMD) is regarded as the ‘gold standard’; nevertheless, studies suggest that the Inventory of Depressive Symptomatology (IDS) is more sensitive to detect symptom changes. The aim of the present study was to investigate whether the IDS is more sensitive in detecting changes in depression symptoms in patients with mild major, minor or subsyndromal depression (MIND).

Methods

Biweekly IDS-C28 and HAMD17 data from 340 patients of a 10-week randomized, placebo-controlled trial comparing the effectiveness of sertraline and cognitive-behavioural therapy in patients with MIND were analysed. We investigated sensitivity to change for both scales

  1. 1) from assessment-to-assessment,

  2. 2) in relation to depression severity level, and

  3. 3) in relation to DSM-IV depression criterion symptoms.

Results

The IDS-C28 was more sensitive in detecting changes in depression symptomatology over the treatment course as well as for different severity levels, especially in patients with a low depression severity. It assesses the DSM-IV criteria more thoroughly, is better able to track the change of cognitive symptoms and to identify residual symptoms.

Conclusions

Both scales are well able to assess depressive symptomatology. However, the IDS-C28 surpasses the HAMD17 in detecting small changes especially in the core symptoms of depression. This is important for an optimal treatment by capturing early improvements, enabling prompt reactions and detecting residual symptoms.

Type
P02-39
Information
European Psychiatry , Volume 26 , Issue S2: Abstracts of the 19th European Congress of Psychiatry , March 2011 , pp. 634
Copyright
Copyright © European Psychiatric Association 2011
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