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Introducing a psychiatric genetic cohort of schizophrenia patients and controls from Vietnam

Published online by Cambridge University Press:  13 August 2021

A. Braun ,
T.V. Nguyen ,
S. Ripke ,
P.V. Nguyen ,
J. Kraft ,
H.T. Nguyen ,
T.C. Le ,
G. Panagiotaropoulou ,
I.M. Hahne  and
K. Böge
...Show all authors
A. Braun*
Affiliation:
Department Of Psychiatry, Charité – Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany
T.V. Nguyen
Affiliation:
Department Of Psychiatry, Hanoi Medical University, Hanoi, VietNam
S. Ripke
Affiliation:
Department Of Psychiatry, Charité – Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany Stanley Center For Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, United States of America
P.V. Nguyen
Affiliation:
Department Of Psychiatry, Hanoi Medical University, Hanoi, VietNam
J. Kraft
Affiliation:
Department Of Psychiatry, Charité – Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany
H.T. Nguyen
Affiliation:
Department Of Psychiatry, Hanoi Medical University, Hanoi, VietNam
T.C. Le
Affiliation:
Department Of Psychiatry, Hanoi Medical University, Hanoi, VietNam
G. Panagiotaropoulou
Affiliation:
Department Of Psychiatry, Charité – Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany
I.M. Hahne
Affiliation:
Department Of Psychiatry, Charité – Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
K. Böge
Affiliation:
Department Of Psychiatry, Charité – Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
E. Hahn
Affiliation:
Department Of Psychiatry, Charité – Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
T.M.T. Ta
Affiliation:
Department Of Psychiatry, Hanoi Medical University, Hanoi, VietNam Department Of Psychiatry, Charité – Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
*
*Corresponding author.

Abstract

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Introduction

Genome-wide association studies (GWAS) have successfully revealed genetic risk variants for schizophrenia (SCZ). However, the vast majority of GWAS largely comprise European samples. As a result, the derived polygenic risk scores (PRS) show decreased predictive power when applied to non-European populations.

Objectives

A long-term scientific cooperation between the Charité Universitätsmedizin Berlin and the Hanoi Medical University aims to address this limitation by recruiting a large genetic cohort of comprehensively phenotyped schizophrenia patients and controls in Vietnam.

Methods

A pilot study was conducted at the Department of Psychiatry of the Medical University Hanoi in 2017. Data collection encompassed i) genome-wide SNP genotyping of 200 schizophrenia patients and 200 control subjects ii) structured interviews to assess symptom severity (PANSS), iii) clinical parameters (e.g. duration of illness, medication) and demography.

Results

SCZ-PRS of the pilot sample (N=400) were generated using different training data sets: i) European, ii) East-Asian and iii) mixed GWAS summary statistics from the Psychiatric Genomics Consortium’s latest discovery sample. Most variance explained was observed using a mixed discovery sample (R2liability=0.053, p=3.11*10-8, Pd <0.5), followed by PRS based on the East-Asian summary statistics (R2liability=0.0503, p=6.78*10-8, Pd <1) and the European sample (R2liability=0.0363, p = 4.26*10-6, Pd <0.01).

Conclusions

With this pilot project we established an efficient recruitment, genotyping and data analysis pipeline. Our results corroborate previous findings indicating that transferability of PRS across populations depends on the ancestral composition of the initial discovery dataset. We therefore aim to expand data collection efforts in the future in order to improve risk prediction across diverse populations.

Disclosure

No significant relationships.

Keywords

Vietnamgeneticsschizophrénia
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S802 - S803
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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