Hostname: page-component-586b7cd67f-rcrh6 Total loading time: 0 Render date: 2024-11-29T01:33:35.288Z Has data issue: false hasContentIssue false
  • English
  • Français

Intrinsic functional connectivity of cortico-basal ganglia-thalamo-cortical circuitry underlying psychomotor retardation in major depressive disorder

Published online by Cambridge University Press:  23 March 2020

Y. Yin ,
Y. Yuan ,
L. Fan ,
C. Xie  and
Z. Zhang
Y. Yin
Affiliation:
Affiliated ZhongDa hospital, institute of neuropsychiatry, Southeast university, department of psychosomatics and psychiatry, school of medicine, Nanjing, China
Y. Yuan
Affiliation:
Affiliated ZhongDa hospital, institute of neuropsychiatry, Southeast university, department of psychosomatics and psychiatry, school of medicine, Nanjing, China
L. Fan
Affiliation:
Institute of automation, Chinese academy of sciences, Brainnetome center, Beijing, China
C. Xie
Affiliation:
ZhongDa hospital, school of medicine, Southeast university, neurology, Nanjing, China
Z. Zhang
Affiliation:
ZhongDa hospital, school of medicine, Southeast university, neurology, Nanjing, China

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Introduction

Psychomotor retardation (PMR) in depression is analogous to the hypokinesia in Parkinson's disease, which is associated with the unbalanced direct and indirect pathways of cortico-basal ganglia-thalamo-cortical (CBTC) circuitry. This study hypothesized PMR in major depressive disorder (MDD) should be associated with the hyperactivity of CBTC indirect pathways.

Objectives

To substantiate the hypothesis that the PMR symptom of MDD might attribute to the hyperactivity of the ortico-basal ganglia-thalamo-cortical indirect pathway which could inhibit psychomotor performance.

Methods

We investigated the intrinsic stiato-subthalamic nucleus (STN)-thalamic functional connectivity (FC), three pivotal hubs of the indirect pathway, in 30 MDD patients with PMR (PMR group) and well matched 30 patients without PMR (NPMR group) at baseline, and 11 patients of each group at follow-up who remitted after antidepressant treatment.

Results

The results showed increased STN-striatum FC of PMR group at baseline and no more discrepancy at follow-up, and significant correlation between PMR severity and thalamo-STN FC.

Conclusions

Our findings suggested the increased STN- striatum FC should be considered as a state biomarker to distinguish MDD patients with PMR from patients without PMR at acute period, and thalamo-STN FC could be identified as the predictor of the PMR severity for MDD patients.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster Walk: Depression - part 3 and obsessive-compulsive disorder
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S328
Copyright
Copyright © European Psychiatric Association 2017
Submit a response

Comments

No Comments have been published for this article.