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Intra-Dorsal Hippocampal Microinjection of Lithium and Scopolamine Induce a Cross State-Dependent Learning in Mice

Published online by Cambridge University Press:  16 April 2020

B. Ghorbanalizadeh-Khalifeh-Mahaleh
Affiliation:
Department of Physiology, Tehran Medical Unit, Islamic Azad University, Tehran, Iran
S. Taheri
Affiliation:
Department of Pharmacology and Iranian National Center for Addiction Studies, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
M. Sahengharani
Affiliation:
Department of Pharmacology and Iranian National Center for Addiction Studies, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
A. Rezayof
Affiliation:
Department of Animal Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran
A. Haeri-Rohani
Affiliation:
Department of Animal Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran
M.-R. Zarrindast
Affiliation:
Department of Pharmacology and Iranian National Center for Addiction Studies, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran School of Cognitive Science, Institute for Studies Theoretical Physics and Mathematics, Tehran, Iran Institute for Cognitive Science Studies, Tehran, Iran

Abstract

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Background:

Lithium a mood stabilizer may exert adverse effects on memory. We have previously shown that lithium induces state-dependent learning. Cholinergic systems of the brain may play an important role in memory function and mood regulation. In the present study, effects of intra-dorsal hippocampal (intra-CA1) injections of lithium and scopolamine on memory and cross state-dependent learning between two drugs were investigated.

Methods:

For memory assessment, a one-trial step-down inhibitory avoidance task was used in adult male NMRI mice.

Results:

Intra-CA1 administration of lithium (0.5 and 1 μg/mouse) after training or injection of the drug (0.5μg/mouse) before testing impaired memory when retrieval was tested 24 h later. The memory impairment by post-training lithium was reversed by pre-test administration of the drug (0.5μg/mouse, intra-CA1) suggesting lithium state-dependent learning. On the other hand, intra-CA1 administration of scopolamine (0.5, 1 and 2 μg/mouse) after training or injection of the drug (2μg/mouse) before testing impaired memory when retrieval was tested 24 h later. The impairment of memory by post-training injection of scopolamine (2μg/mouse) was restored by the pre-test injection of the drug (1 and 2 μg/mouse). Furthermore, memory impairment induced by post-training injection of lithium (0.5 μg/mouse) and scopolamine (2 μg/mouse) were reversed by pre-test administration of scopolamine (0.5, 1 and 2 μg/mouse) and lithium (0.5 and 1 μg/mouse) respectively. The impairment by lithium was also reversed by physostigmine.

Conclusion:

The results suggest that microinjection of both lithium and scopolamine induce state-dependent memory and there may be a cross state-dependency between two drugs.

Type
P02-168
Copyright
Copyright © European Psychiatric Association 2009
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