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Intra-Dorsal Hippocampal Microinjection of Lithium and Scopolamine Induce a Cross State-Dependent Learning in Mice
Published online by Cambridge University Press: 16 April 2020
Abstract
Lithium a mood stabilizer may exert adverse effects on memory. We have previously shown that lithium induces state-dependent learning. Cholinergic systems of the brain may play an important role in memory function and mood regulation. In the present study, effects of intra-dorsal hippocampal (intra-CA1) injections of lithium and scopolamine on memory and cross state-dependent learning between two drugs were investigated.
For memory assessment, a one-trial step-down inhibitory avoidance task was used in adult male NMRI mice.
Intra-CA1 administration of lithium (0.5 and 1 μg/mouse) after training or injection of the drug (0.5μg/mouse) before testing impaired memory when retrieval was tested 24 h later. The memory impairment by post-training lithium was reversed by pre-test administration of the drug (0.5μg/mouse, intra-CA1) suggesting lithium state-dependent learning. On the other hand, intra-CA1 administration of scopolamine (0.5, 1 and 2 μg/mouse) after training or injection of the drug (2μg/mouse) before testing impaired memory when retrieval was tested 24 h later. The impairment of memory by post-training injection of scopolamine (2μg/mouse) was restored by the pre-test injection of the drug (1 and 2 μg/mouse). Furthermore, memory impairment induced by post-training injection of lithium (0.5 μg/mouse) and scopolamine (2 μg/mouse) were reversed by pre-test administration of scopolamine (0.5, 1 and 2 μg/mouse) and lithium (0.5 and 1 μg/mouse) respectively. The impairment by lithium was also reversed by physostigmine.
The results suggest that microinjection of both lithium and scopolamine induce state-dependent memory and there may be a cross state-dependency between two drugs.
- Type
- P02-168
- Information
- European Psychiatry , Volume 24 , Issue S1: 17th EPA Congress - Lisbon, Portugal, January 2009, Abstract book , January 2009 , 24-E858
- Copyright
- Copyright © European Psychiatric Association 2009
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