Hostname: page-component-78c5997874-94fs2 Total loading time: 0 Render date: 2024-11-05T03:53:34.420Z Has data issue: false hasContentIssue false

Interindividual variation of cerebral activation during encoding and retrieval of words

Published online by Cambridge University Press:  16 April 2020

R Heun*
Affiliation:
Department of Psychiatry, University of Bonn, Venusberg, D-53105Bonn, Germany
F Jessen
Affiliation:
Department of Psychiatry, University of Bonn, Venusberg, D-53105Bonn, Germany
U Klose
Affiliation:
Section Experimental NMR of the CNS, Department of Neuroradiology, University of Tübingen, Tübingen, Germany
M Erb
Affiliation:
Section Experimental NMR of the CNS, Department of Neuroradiology, University of Tübingen, Tübingen, Germany
D.O Granath
Affiliation:
Department of Psychiatry, University of Bonn, Venusberg, D-53105Bonn, Germany
N Freymann
Affiliation:
Department of Psychiatry, University of Bonn, Venusberg, D-53105Bonn, Germany
W Grodd
Affiliation:
Section Experimental NMR of the CNS, Department of Neuroradiology, University of Tübingen, Tübingen, Germany
*
*Correspondence and reprints. Email-address: [email protected] (R. Heun).
Get access

Extract

The aim of the present study was to compare the cerebral activation associated with encoding and retrieval in individual subjects with the average activation in the same group of subjects. Twelve volunteers performed two paradigms: 1) intentional encoding of words, and 2) recognition of learned words intermixed with new distracters. Echo-planar magnetic resonance imaging (MRI) of BOLD signal changes was used to compare cerebral activation between active and resting conditions. During encoding, activation of the left precentral gyrus related to the motor response was observed in some subjects. Averaged data showed increased activation of the left precentral gyrus, the supplementary motor area (SMA), the left inferior frontal gyrus and in the left temporo-occipital junction. During recognition, motor response-related activity was found in the precentral cortex and SMA in most subjects. Activation in other brain areas showed considerable interindividual variation. In the entire group, recognition showed activation of the left dorsolateral prefrontal cortex, the precentral gyrus, the SMA, and the temporo-occipital junction. The total amount and the distribution of task-related cerebral activation varies considerably between individuals and might correspond to individual preferences of cognitive strategies. The investigation of these interindividual variations will be an exciting scientific challenge in the near future.

Type
Original article
Copyright
Copyright © 2001 Éditions scientifiques et médicales Elsevier SAS. All rights reserved

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Andreasen, NCO’Leary, DSArndt, SCizadlo, THurtig, RRezai, K et al. Short-term and long-term verbal memory: a positron emission tomography study Proc Natl Acad Sci U S A 1995; 92: 5111–5115CrossRefGoogle ScholarPubMed
Baschek, ILBredenkamp, JOehrle, BWippich, WBestimmung der Bildhaftigkeit (I), Konkretheit (C) und der Bedeutungshaltigkeit (m’) von 800 Substantiven Z Exp Angew Psychol 1977; 24: 353–396Google Scholar
Buckner, RLPetersen, SEOjemann, JGMiezin, FMSquire, LRReichle, MEFunctional anatomical studies of explicit and implicit memory retrieval tasks J Neurosci 1995; 15: 12–29CrossRefGoogle ScholarPubMed
Demb, JBDesmond, JEWagner, ADVaidya, CJGlover, GHGabrieli, J.D.ESemantic encoding and retrieval in the left inferior prefrontal cortex: a functional MRI study of task difficulty and process specificity J Neurosci 1995; 15: 5870–5878CrossRefGoogle ScholarPubMed
Dolan, RJFletcher, PCDissociating prefrontal and hippocampal function in episodic memory encoding Nature 1997; 388: 582–585CrossRefGoogle ScholarPubMed
Fletcher, PCFrith, CDGrasby, PMShallice, TFrackowiak, R.S.JDolan, RJBrain systems for encoding and retrieval of auditory-verbal memory. An in vivo study in humans Brain 1995; 118: 401–416CrossRefGoogle Scholar
Fletcher, PCFrith, CDRugg, MDThe functional neuroanatomy of episodic memory Trends Neurosci 1997; 20: 213–218CrossRefGoogle ScholarPubMed
Friston, KJStatistical parametric mapping and other analyses of functional imaging dataToga, AWMazziotta, JCBrain mapping. The methods 1996 Academic Press San Diego, New York363–386Google Scholar
Grady, CLMcIntosh, ARHorwitz, BMaisog, JMUngerleider, LGMentis, MJ et al. Age-related reductions in human recognition memory due to impaired encoding Science 1995; 269: 218–221CrossRefGoogle ScholarPubMed
Heun, RKlose, UJessen, FErb, MPapassotiropoulos, ALotze, M et al. Functional MRI of cerebral activation during encoding and retrieval of words Hum Brain Mapp 1999; 8: 157–1693.0.CO;2-G>CrossRefGoogle Scholar
Klose, UErb, MWildgruber, DMüller, EGrodd, WImprovement of the acquisition of a large amount of MR images on a conventional whole body system Magn Reson Imag 1999; 17: 471–474CrossRefGoogle ScholarPubMed
Le Bihan, DTurner, RZeffiro, TACuénod, CAJezzard, PBonnerot, VActivition of human primary visual cortex during visual recall: a magnetic resonance imaging study Proc Natl Acad Sci U S A 1993; 90: 11802–11805CrossRefGoogle Scholar
McCarthy, GBlamire, AMPuce, ANobre, ACBloch, GHyder, F et al. Functional magnetic resonance imaging of human prefrontal cortex activation during a spatial working memory task Proc Natl Acad Sci U S A 1994; 91: 8690–8694CrossRefGoogle ScholarPubMed
Oldfield, RCThe assessment and analysis of handedness: the Edinburgh Inventory Neuropsychologia 1971; 9: 97–113CrossRefGoogle ScholarPubMed
Oldigs-Kerber, JAdamus, WSKitzinger, MZur Beeinflussung von verbalen Lern- und Gedächtnisprozessen durch Anticholinergica am Beispiel von Scopolamin. Ein pharmakopsychologischer Beitrag für die neuropsychologische Praxis Z Neuropsychol 1991; 2: 29–40Google Scholar
Riddle, WO’Carroll, REDougall, NVan Beck, MMurray, CCurran, SM et al. A single photon emission computerised tomography study of regional brain function underlying verbal memory in patients with Alzheimer-type dementia Br J Psychiatry 1993; 163: 166–172CrossRefGoogle ScholarPubMed
Schacter, DLAlpert, NMSavage, CRRauch, SLAlbert, MSConscious recollection and the human hippocampal formation: evidence from positron emission tomography Proc Natl Acad Sci U S A 1996; 93: 321–325CrossRefGoogle ScholarPubMed
Schacter, DLBuckner, RLKoutstaal, WDale, AMRosen, BRLate onset of anterior prefrontal activity during true and false recognition: an event related fMRI study Neuro Image 1997; 6: 259–269Google ScholarPubMed
Schacter, DLReiman, EUecker, APolster, MRSheng Yun, LBrain regions associated with retrieval of structurally coherent visual information Nature 1995; 376: 587–590CrossRefGoogle ScholarPubMed
Shallice, TFletcher, PFrith, CDGrasby, PFrackowiak, R.S.JDolan, RJBrain regions associated with acquisition and retrieval of verbal episodic memory Nature 1994; 368: 633–635CrossRefGoogle ScholarPubMed
Stern, CECorkin, SGonzáles, RGGuimaraes, ARBaker, JRJennings, PJ et al. The hippocampal formation participates in new picture encoding: evidence from functional magnetic resonance imaging Proc Natl Acad Sci U S A 1996; 93: 8660–8665CrossRefGoogle Scholar
Tulving, EKapur, SMarkowitsch, HJCraik, F.I.MHabib, RHoule, SNeuroanatomical correlates of retrieval in episodic memory: auditory sentence recognition Proc Natl Acad Sci U S A 1994; 91: 2012–2015CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.