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Initial evidence for sex-specific effects of early emotional abuse on affective processing in bipolar disorder

Published online by Cambridge University Press:  15 April 2020

M. Russo ,
R. Proujansky ,
A. Gilbert ,
R.J. Braga  and
K.E. Burdick
M. Russo*
Affiliation:
Department of Psychiatry, Mount Sinai School of Medicine, 1, Gustave-L-Levy-Place, Box 1230, 10029New York, USA
R. Proujansky
Affiliation:
Department of Psychiatry, Mount Sinai School of Medicine, 1, Gustave-L-Levy-Place, Box 1230, 10029New York, USA
A. Gilbert
Affiliation:
The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Department of Psychiatry Research, Glen Oaks, 1, Gustave-L Levy-PlaceBox 1230, 10029New York, USA
R.J. Braga
Affiliation:
The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Department of Psychiatry Research, Glen Oaks, 1, Gustave-L Levy-PlaceBox 1230, 10029New York, USA
K.E. Burdick
Affiliation:
Department of Psychiatry, Mount Sinai School of Medicine, 1, Gustave-L-Levy-Place, Box 1230, 10029New York, USA
*
*Corresponding author. Tel.: +1 212 241 0755; fax: +1 212 996 8931. E-mail address:[email protected] (M. Russo).
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Abstract

Purpose

This study investigates the effect of sex and childhood trauma on affective processing in bipolar disorder (BPD) patients.

Methods

In a sample of fifty-six BPD patients, we administered the Childhood Trauma Questionnaire (CTQ), and the Iowa Gambling Task (IGT) and the Affective Go/No-Go (AGNG) to measure affective processing. Analysis of Variance (ANOVA) was used to evaluate the effect of sex and childhood trauma on IGT; Repeated-Measures ANOVAs to measure accuracy and bias measures across conditions on the AGNG.

Results

In the context of childhood abuse, females evidenced a more conservative cognitive style than males by selecting fewer cards from the disadvantageous decks [F(1, 49) = 14.218; P < 0.001] and showed an improvement throughout the task, as noted in a normal learning curve [F(1.49) = 4.385; P = 0.041)]. For the AGNG, an interaction specific to the negative valence stimuli on response bias measures was found. Abused females scored higher (mean = 8.38; SD = 6.39) than abused males (mean = 0.69; SD = 1.19) [F(1.46) = 6.348; P = 0.015].

Conclusion

Severity of childhood trauma was significantly different between sexes. In the context of a history of emotional abuse, male bipolar patients tended toward a more risk-taking behavior compared to female. Further investigations are needed to elucidate potential pathophysiological mechanisms underlying this interaction.

Keywords

Childhood traumaAffective processingBipolar disorderIowa Gambling TestAffective Go/No-Go
Type
Original article
Information
European Psychiatry , Volume 29 , Issue 1 , January 2014 , pp. 52 - 57
Copyright
Copyright © 2013 Elsevier Masson SAS

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References

Adida, M.Clark, L.Pomietto, P.Kaladjian, A.Besnier, N.Azorin, J.M.et al.Lack of insight may predict impaired decision making in manic patients. Bipolar Disord 2008;10:829–837.CrossRefGoogle ScholarPubMed
Adida, M.Jollant, F.Clark, L.Besnier, N.Guillame, S.Kaladjian, A.et al.Trait-related decision-making impairment in the three phases of bipolar disorder. Biol Psychiatry 2011;70:357–365.CrossRefGoogle ScholarPubMed
Altman, E.G.Hedeker, D.R.Janicak, P.G.Peterson, J.L.Davis, J.M.The clinician-administered rating scale for mania (CARS-M): development, reliability, and validity. Biol Psychiatry 1994;36:24–134.CrossRefGoogle Scholar
Bechara, A.Damasio, H.Damasio, A.R.Emotion, decision making and the orbitofrontal cortex. Cereb Cortex 2000;10:295–307.CrossRefGoogle ScholarPubMed
Bernstein, D.P.Fink, L.Childhood Trauma Questionnaire. A retrospective self-report manual. San Antonio: The Psychological Corporation; 1998.Google Scholar
Bolla, K.I.Eldreth, D.A.Matochik, J.A.Cadet, J.L.Sex-related differences in a gambling task and its neurological correlates. Cereb Cortex 2004;14:1226–1232.CrossRefGoogle Scholar
Bora, E.Harrison, B.J.Yücel, M.Pantelis, C.Cognitive impairment in euthymic major depressive disorder: a meta-analysis. Psychol Med 2012;26:1–10.Google Scholar
Brambilla, P.Cerruti, S.Bellani, M.Perlini, C.Ferro, A.Marinelli, V.et al.Shared impairment in associative learning in schizophrenia and bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry 2011;35:1093–1099.CrossRefGoogle ScholarPubMed
Brambilla, P.Perlini, C.Bellani, M.Tomelleri, L.Ferro, A.Cerruti, S.et al.Increased salience of gains versus decreased associative learning differentiate bipolar disorder from schizophrenia during incentive decision-making. Psychol Med 2012;12:1–10.Google Scholar
Brand, J.G.Goldberg, T.E.Gunawardane, N.Gopin, C.B.Powers, R.L.Malhotra, A.K.et al.Emotional bias in unaffected siblings of patients with bipolar I disorder. J Affect Disord 2012;136:1053–1058.CrossRefGoogle ScholarPubMed
Burdick, K.E.Goldberg, T.E.Cornblatt, B.A.Keefe, R.S.Gopin, C.B.Derosse, P.et al.The MATRICS Consensus Cognitive Battery in patients with bipolar I disorder. Neuropsychopharmacology 2011;36:1587–1592.CrossRefGoogle ScholarPubMed
Busemeyer, J.R.Stout, J.C.A contribution of cognitive decision models to clinical assessment: decomposing performance on the Bechara gambling task. Psychol Assess 2002;14:253–262.CrossRefGoogle ScholarPubMed
Chandler, R.A.Wakeley, J.Goodwin, G.M.Rogers, R.D.Altered risk-aversion and risk-seeking behavior in bipolar disorder. Biol Psychiatry 2009;66:840–846.CrossRefGoogle ScholarPubMed
Daruy-Filho, L.Brietzke, E.Lafer, B.Grassi-Oliveira, R.Childhood maltreatment and clinical outcomes of bipolar disorder. Acta Psychiatr Scand 2011;124:427–434.CrossRefGoogle ScholarPubMed
Diflorio, A.Jones, I.Is sex important? Gender differences in bipolar disorder. Int Rev Psychiatry 2010;22:437–452.CrossRefGoogle ScholarPubMed
Etain, B.Mathieu, F.Henry, C.Raust, A.Roy, I.Germain, A.et al.Preferential association between childhood emotional abuse and bipolar disorder. J Trauma Stress 2010;23:376–383.Google ScholarPubMed
First, M.B.Spitzer, R.L.Gibbon, M.Williams, J.B.W.Structured clinical interview for DSM-IV-TR axis I disorders. Research version Patient Edition (SCIDI/P). New York: Biometrics Research; 2002.Google Scholar
Garno, J.L.Goldberg, J.F.Ramirez, P.M.Ritzler, B.A.Impact of childhood abuse on the clinical course of bipolar disorder. Br J Psychiatry 2005;186:121–125.CrossRefGoogle ScholarPubMed
George, M.S.Huggins, T.McDermut, W.Parekh, P.I.Rubinow, D.Post, R.M.Abnormal facial emotion recognition in depression: serial testing in an ultra-rapid-cycling patient. Behav Modif 1998;22:192–204.CrossRefGoogle Scholar
Gopin, C.B.Burdick, K.E.DeRosse, P.Goldberg, T.E.Malhotra, A.K.Emotional modulation of response inhibition in stable patients with bipolar I disorder: a comparison with healthy and schizophrenia subjects. Bipolar Disord 2011;13:164–172.CrossRefGoogle ScholarPubMed
In: Goldberg, J.F.Burdick, K.E.Cognitive dysfunction in bipolar disorder: a guide for clinicians. Washington, DC: American Psychiatric Publishing, Inc; 2008. p. 1–22.Google Scholar
Guyer, A.E.McClure, E.B.Adler, A.D.Brotman, M.A.Rich, B.A.Kimes, A.S.et al.Specificity of facial expression labeling deficits in childhood psychopathology. J Child Psychol Psychiatry 2007;48:863–871.CrossRefGoogle ScholarPubMed
Hamilton, M.A rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23:56–62.CrossRefGoogle ScholarPubMed
Janssen, I.Krabbendam, L.Bak, M.Hanssen, M.Vollebergh, W.de Graaf, R.et al.Childhood abuse as a risk factor for psychotic experiences. Acta Psychiatr Scand 2004;109:38–45.CrossRefGoogle ScholarPubMed
Jogia, J.Dima, D.Frangou, S.Sex differences in bipolar disorder: a review of neuroimaging findings and new evidence. Bipolar Disord 2012;14:461–471.CrossRefGoogle ScholarPubMed
Lagopoulos, J.Malhi, G.S.A functional magnetic resonance imaging study of emotional Stroop in euthymic bipolar disorder. Neuroreport 2007;18:1583–1587.CrossRefGoogle ScholarPubMed
Lennox, B.R.Jacob, R.Calder, A.J.Lupson, V.Bullmore, E.T.Behavioural and neurocognitive responses to sad facial affect are attenuated in patients with mania. Psychol Med 2004;34:795–802.CrossRefGoogle ScholarPubMed
Leverich, G.S.McElroy, S.L.Suppes, T.Keck, P.E. Jr.Denicoff, K.D.Nolen, W.A.et al.Early physical and sexual abuse associated with an adverse course of bipolar illness. Biol Psychiatry 2002;51:288–297.CrossRefGoogle ScholarPubMed
Levitan, R.D.Parikh, S.V.Lesage, A.D.Hegadoren, K.M.Adams, M.Kennedy, S.H.et al.Major depression in individuals with a history of childhood physical or sexual abuse: relationship to neurovegetative features, mania, and gender. Am J Psychiatry 1998;155:1746–1752.CrossRefGoogle ScholarPubMed
Manes, F.Sahakian, B.Clark, L.Rogers, R.Antoun, N.Aitken, M.et al.Decision-making processes following damage to the prefrontal cortex. Brain 2002;125:624–639.CrossRefGoogle ScholarPubMed
Morgan, C.Fisher, H.Environment and schizophrenia: environmental factors in schizophrenia: childhood trauma-a critical review. Schizophr Bull 2007;33:3–10.CrossRefGoogle ScholarPubMed
Nemeroff, C.B.Neurobiological consequences of childhood trauma. J Clin Psychiatry 2004;65:18–28.Google ScholarPubMed
Neria, Y.Bromet, E.J.Carlson, G.A.Naz, B.Assaultive trauma and illness course in psychotic bipolar disorder: findings from the Suffolk county mental health project. Acta Psychiatr Scand 2005;111:380–383.CrossRefGoogle ScholarPubMed
Nilsson, K.K.Jørgensen, C.R.Craig, T.K.Straarup, K.N.Licht, R.W.Self-esteem in remitted bipolar disorder patients: a meta-analysis. Bipolar Disord 2010;12:585–592.CrossRefGoogle ScholarPubMed
Nivoli, A.M.Pacchiarotti, I.Rosa, A.R.Popovic, D.Murru, A.Valenti, M.et al.Gender differences in a cohort study of 604 bipolar patients: the role of predominant polarity. J Affect Disord 2011;133:443–449.CrossRefGoogle Scholar
Reavis, R.Overman, W.H.Adult sex differences on a decision-making task previously shown to depend on the orbital prefrontal cortex. Behav Neurosci 2001;115:196–206.CrossRefGoogle ScholarPubMed
Roiser, J.Farmer, A.Lam, D.Burke, A.O’Neil, N.Keating, N.et al.The effect of positive mood induction on emotional processing in euthymic individuals with bipolar disorder and controls. Psychol Med 2009;39:785–791.CrossRefGoogle ScholarPubMed
Savitz, J.B.van der Merwe, L.Stein, D.J.Solms, M.Ramesar, R.S.Neuropsychological task performance in bipolar spectrum illness: genetics, alcohol abuse, medication, and childhood trauma. Bipolar Disord 2008;10:479–494.CrossRefGoogle ScholarPubMed
Venn, H.R.Gray, J.M.Montagne, B.Murray, L.K.Michael Burt, D.Frigerio, E.et al.Perception of facial expressions of emotion in bipolar disorder. Bipolar Disord 2004;6:286–293.CrossRefGoogle ScholarPubMed
Wessa, M.Linke, J.Emotional processing in bipolar disorder: behavioural and neuroimaging findings. Int Rev Psychiatry 2009;21:357–367.CrossRefGoogle ScholarPubMed
Whittle, S.Yücel, M.Yap, M.B.Allen, N.B.Sex differences in the neural correlates of emotion: evidence from neuroimaging. Biol Psychol 2011;87:319–333.CrossRefGoogle ScholarPubMed
Wilkinson, G.S.Wide-Range Achievement Test 3: administration manual. Wilmington: Wide Range; 1993.Google Scholar
Yechiam, E.Hayden, E.P.Bodkins, M.O’Donnell, B.F.Hetrick, W.P.Decision making in bipolar disorder: a cognitive modeling approach. Psychiatry Res 2008;161:142–152.CrossRefGoogle ScholarPubMed
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