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Inflammatory Markers in Obsessive-Compulsive Disorder: A Systematic Review and Meta-Analysis

Published online by Cambridge University Press:  01 September 2022

M. Constable  and
R. Hou
M. Constable*
Affiliation:
University of Southampton, Faculty Of Medicine, Southampton, United Kingdom
R. Hou
Affiliation:
University of Southampton, Department Of Psychiatry, Southampton, United Kingdom
*
*Corresponding author.

Abstract

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Introduction

A growing number of studies have examined the link between inflammatory markers (IM) and the pathophysiology of obsessive-compulsive disorder (OCD). However, this association has yet to be fully identified.

Objectives

This review aims to systematically evaluate evidence from studies examining peripheral IM in adult participants with OCD compared to controls. IM included: CRP, TNFa, IFNγ, IL1/4/6/10.

Methods

Databases used for literature searching: Medline, Embase, PsycINFO (until October 2021). Studies that examined IM in the blood of adult OCD and control groups were included. Screening and data extraction adhered to PRISMA guideline standards. The quality assessment utilised funnel plots and the approach developed by Hawker et al. 2002. A random-effects meta-analysis model was adopted. PROSPERO reference number: CRD42021284766.

Results

The systematic review (19 studies, 1,225 participants) and meta-analysis (12 studies, 796 participants) had an average quality assessment score of 28.3 (medium quality) and 30.7 (high quality), respectively. The average heterogeneity of each IM analysed was 76.6%. Totalled, each study and IM analysis showed more insignificant differences (n=35) than significant differences (n=25). The meta-analysis revealed no significant difference for overall IM assessments. However, a sub-analysis of IL6 (excluding studies using serum or lipopolysaccharide stimulation) found significantly lower levels of IL6 within the OCD group (effect size: 3.98 and 95% CI: 0.43,7.53).

Conclusions

This is an up-to-date systematic review examining IM in OCD. Insignificant results found may have resulted from the relatively high heterogeneity or varied study designs. One sub-analysis of IL6 identified an association, although further studies are required with larger sample sizes and fewer disparities.

Disclosure

No significant relationships.

Keywords

inflammatory markerssystematic reviewpsychiatryobsessive-compulsive disorder
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S295
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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