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Inflammation and autoimmune indicators in the differential diagnosis of autism spectrum disorders in children

Published online by Cambridge University Press:  01 September 2022

L. Androsova ,
N. Simashkova ,
S. Zozulya ,
O. Shushpanova ,
I. Otman  and
T. Klyushnik
L. Androsova*
Affiliation:
Mental Health Research Centre, Laboratory Of Neuroimmunology, Moscow, Russian Federation
N. Simashkova
Affiliation:
Mental Health Research Centre, Department Of Childhood Psychiatry, Moscow, Russian Federation
S. Zozulya
Affiliation:
Mental Health Research Centre, Laboratory Of Neuroimmunology, Moscow, Russian Federation
O. Shushpanova
Affiliation:
Mental Health Research Centre, Department Of Childhood Psychiatry, Moscow, Russian Federation
I. Otman
Affiliation:
Mental Health Research Centre, Laboratory Of Neuroimmunology, Moscow, Russian Federation
T. Klyushnik
Affiliation:
Mental Health Research Centre, Laboratory Of Neuroimmunology, Moscow, Russian Federation
*
*Corresponding author.

Abstract

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Introduction

Autism spectrum disorders (ASD) is one of the most urgent problems of psychiatry because of their high prevalence, diagnostic difficulties as well as insufficient knowledge of the pathogenetic mechanisms.

Objectives

To determine the number of inflammation markers in patients with various forms of ASD in links with features of a clinical condition for creating diagnostic criteria for differential diagnosis and improve reliability.

Methods

The clinical examination of patients (135 children with various ASD forms) was carried out by using psychometric scales (CARS, BFCRS, CGI-S). The activity of inflammation markers (LE and α1-PI) and the level of autoantibodies to S-100b and MBP were measured in plasma. Complex evaluation of immune system activation was also conducted, taking into consideration interactions of innate and adaptive immunity.

Results

Non-psychotic ASD forms (Asperger’s syndrome and Kanner’s syndrome) were not accompanied by a change of the immunological indices in comparison with control. In psychotic ASD forms, a significant increase of the studied indices was revealed (р<0.05). Correlation between the complex evaluation of the immune system activation and the stage of the disease (r=0.49, р<0.05) was demonstrated. Also the significant correlations between the severity of autistic disorders according to CARS (r=0.48, p<0.05), catatonic disorders by BFCRS (r=0.42, p<0.05), and the assessment by CGI (r= 0.61, p<0.05) were observed.

Conclusions

The immune markers as well as their complex evaluation may be used as additional diagnostic criteria in the clinical examination for differential ASD diagnostics and assessment of the quality of remission, and also monitoring of the patient condition.

Disclosure

No significant relationships.

Keywords

autism spectrum disordersdifferential diagnosisinflammation amd autoimmune markers
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S364
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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