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Increased serum drug concentrations in concomitant treatment with citalopram, clomipramine and alprazolam

Published online by Cambridge University Press:  16 April 2020

U Lepola ,
E Leinonen  and
H Koponen
U Lepola
Affiliation:
Psychiatric Research Clinic of Kuopio, Asemakatu 46 B, SF-70110Kuopio
E Leinonen
Affiliation:
Psychiatric Research Clinic of Kuopio, Asemakatu 46 B, SF-70110Kuopio
H Koponen
Affiliation:
Moisio Hospital, Mikkeli, Finland
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Summary

We report the case of a patient with major depression and obsessive-compulsive disorder who had simultaneously high serum citalopram, clomipramine, and alprazolam concentrations probably due to the reciprocal competitive inhibition of the cytochrome P450-catalyzed oxidative metabolism.

Keywords

alprazolamcitalopramclomipraminecytochrome P450drug interaction
Type
Case report
Information
European Psychiatry , Volume 9 , Issue 6 , 1994 , pp. 312 - 314
Copyright
Copyright © European Psychiatric Association 1994

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References

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