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Impaired response inhibition in obsessive compulsive disorder

Published online by Cambridge University Press:  28 November 2006

R. Penadés ,
R. Catalán ,
K. Rubia ,
S. Andrés ,
M. Salamero  and
C. Gastó
R. Penadés*
Affiliation:
Clinical Institute of Neurosciences, Hospital Clínic, C/ Villarroel 170, 08036Barcelona, Spain
R. Catalán
Affiliation:
Clinical Institute of Neurosciences, Hospital Clínic, C/ Villarroel 170, 08036Barcelona, Spain
K. Rubia
Affiliation:
Institute of Psychiatry, King’s College, London, UK
S. Andrés
Affiliation:
Clinical Institute of Neurosciences, Hospital Clínic, C/ Villarroel 170, 08036Barcelona, Spain
M. Salamero
Affiliation:
Clinical Institute of Neurosciences, Hospital Clínic, C/ Villarroel 170, 08036Barcelona, Spain
C. Gastó
Affiliation:
Clinical Institute of Neurosciences, Hospital Clínic, C/ Villarroel 170, 08036Barcelona, Spain
*
∗Corresponding author. Tel./fax: +34 93 227 54 77. E-mail address: [email protected] (R. Penadés).
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Abstract

Objective

The present study investigates different three inhibitory control functions in patients with obsessive-compulsive disorder (OCD). Selective motor response inhibition was tested in a GO/NO-GO paradigm, the inhibition of a triggered motor response in a STOP paradigm and the ability to inhibit cognitive interference in a motor STROOP paradigm.

Methods

27 patients who met DSM-IV criteria for OCD and 25 age, handedness and IQ-matched healthy control subjects were tested in the GO/NO-GO, STOP and motor STROOP tasks.

Results

OCD patients performed significantly worse than controls in the selective inhibition of their motor responses (GO/NO-GO) and in the inhibition of cognitive interference (STROOP), and also showed worse performance in suppressing previously triggered motor responses (STOP).

Conclusion

Patients with OCD are impaired in motor and cognitive inhibitory mechanisms. The findings are consistent with psychobiological and neuropsychological models of OCD suggesting impairment of frontostriatal circuitries that mediate functions of inhibitory control.

Keywords

Obsessive compulsive disorderGO/NO-GO taskSTOP taskSTROOP taskCognitive inhibitionMotor response inhibition
Type
Original article
Information
European Psychiatry , Volume 22 , Issue 6 , September 2007 , pp. 404 - 410
Copyright
Copyright © Elsevier Masson SAS 2007

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