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The Impact of Relapses in Acute Schizophrenia's Clinical Outcome: A Descriptive Cross-sectional Analysis

Published online by Cambridge University Press:  23 March 2020

I. Carreira Figueiredo ,
D. Pereira ,
I. Cargaleiro  and
P. Aguiar
I. Carreira Figueiredo
Affiliation:
Centro Hospitalar Psiquiátrico de Lisboa, Psychiatry, Lisboa, Portugal
D. Pereira
Affiliation:
Centro Hospitalar Psiquiátrico de Lisboa, Psychiatry, Lisboa, Portugal
I. Cargaleiro
Affiliation:
Centro Hospitalar Psiquiátrico de Lisboa, Psychiatry, Lisboa, Portugal
P. Aguiar
Affiliation:
Escola Nacional de Saúde Pública, Statistics and Statistical Methods in Clinical Epidemiology, Lisboa, Portugal

Abstract

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Introduction

Recent studies suggest that most of schizophrenia's first-episode patients have the potential for long-term remission. Conversely, some meta-analysis estimate the actual median recovery rate to be 13.5% [1]. Relapses may contribute to the emergence of increased morbidity and treatment resistance.

Objectives

To evaluate possible relationships between the numbers of previous admissions, years of diagnosed disease and hospitalization length.

Methods

A cross-sectional retrospective study on all patients (n = 202, 150 men and 52 women) admitted at an acute inpatient unit throughout the year of 2015, diagnosed with schizophrenia (ICD-9, 295). Collection of socio-demographic data, number of previous admissions (PA), years of diagnosed disease (YDD) and hospitalization length (HL). Descriptive statistical analysis, Spearman rank correlation and Mann-Whitney U test.

Results

Overall, the sample's mean age was 44.3 years old (std 12.7), being lower in men (42.5 versus 49.7). The average of admissions was 1.2 per year. PA and YDD were significantly associated (P < 0.0001). Contrarily, there was no statistical association between the number of PA and HL (P > 0.1), as well as between YDD and HL (P > 0.1) was found.

Conclusion

This study provides additional evidence for schizophrenia's early onset in men. There seems to be no association between relapses and treatment resistance, considering PA, YDD and HL as valuable soft outcomes. Future understanding of relapses’ pathophysiological mechanisms is warranted in order to explain schizophrenia's low median recovery rate.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
Oral communications: Rehabilitation and psychoeducation and schizophrenia and other psychotic disorders
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S105
Copyright
Copyright © European Psychiatric Association 2017

References

Catts, S.V., O’Toole, B.I.The treatment of schizophrenia: can we raise the standard of care? Aust N Z J Psychiatry 2016; 50: 1128–113810.1177/0004867416672725CrossRefGoogle ScholarPubMed
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