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Hormonal alterations due to antipsychotic-related hyperprolactinemia

Published online by Cambridge University Press:  01 September 2022

A.L. Montejo ,
B. Buch ,
M.J. López ,
M.T. Arias ,
M.D. Corrales ,
E. Dominguez ,
C. Matos ,
B. Cortés ,
Y. Santana  and
I. Valrriberas
...Show all authors
A.L. Montejo*
Affiliation:
University of Salamanca, Psychiatry, Salamanca, Spain
B. Buch
Affiliation:
IBSAL, Neurociencias, Salamanca, Spain
M.J. López
Affiliation:
hospital universitario, Psiquiatría, salamanca, Spain
M.T. Arias
Affiliation:
hospital universitario, Psiquiatría, salamanca, Spain
M.D. Corrales
Affiliation:
hospital universitario, Psiquiatría, salamanca, Spain
E. Dominguez
Affiliation:
hospital universitario, Psiquiatría, salamanca, Spain
C. Matos
Affiliation:
hospital universitario, Psiquiatría, salamanca, Spain
B. Cortés
Affiliation:
hospital universitario, Psiquiatría, salamanca, Spain
Y. Santana
Affiliation:
hospital universitario, Psiquiatría, salamanca, Spain
I. Valrriberas
Affiliation:
hospital universitario, Psiquiatría, salamanca, Spain
J. Matías
Affiliation:
hospital universitario, Psiquiatría, salamanca, Spain
T. Prieto
Affiliation:
IBSAL, Neurociencias, Salamanca, Spain
J.M. Acosta
Affiliation:
IBSAL, Neurociencias, Salamanca, Spain
*
*Corresponding author.

Abstract

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Introduction

The use of antipsychotics (APS) is essential. Despite their great efficacy, some of them are associated with an increase in prolactin levels that can lead to hormonal changes needing to be identified and managed [1,2,3]. Hormonal changes use to have clinical implications including hypogonadism, infertility and sexual dysfunction

Objectives

To evaluate possible hormonal alterations and some clinical implications produced by hyperprolactinemia (HPRL) derived from the use of some antipsychotic compounds.

Methods

A complete fasting blood test was performed on a sample of 113 subjects (69 men and 44 women). 54% (n = 61) showed a normal prolactin level and 46% (n = 52) showed hyperprolactinaemia ( >50ng / ml). On the global sample, 39.8% (n = 45) was treated with some hyperprolactinemic drug , mostly risperidone and paliperidone.

Results

Some differences were found depending on the gender of the subjects. A highly significant inverse relationship between the values of prolactin and testosterone was found in males (p=0.020, r=-0.285). In females, increased prolactin level was significantly related to decreased cortisol values.

Conclusions

Antipsychotic-related Hyperprolactinaemia ( mainly risperidone and paliperidone) is related with a decrease in testosterone levels in males and with an increase in cortisol levels in females.

Disclosure

No significant relationships.

Keywords

antipsychoticschizophréniaprolactiniatrogenic
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S782
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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