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High Cognitive Reserve in Bipolar Disorders as a Moderator of Neurocognitive Impairment

Published online by Cambridge University Press:  23 March 2020

I. Grande ,
J. Sanchez-Moreno ,
B. Solé ,
E. Jimenez ,
C. Torrent ,
C.D.M. Bonnin ,
C. Varo ,
R. Tabarés-Seisdedos ,
V. Balanza-Martínez  and
E. Valls
...Show all authors
I. Grande
Affiliation:
Hospital Clinic de Barcelona, Psychiatry, Barcelona, Spain
J. Sanchez-Moreno
Affiliation:
Hospital Clinic de Barcelona, Psychiatry, Barcelona, Spain
B. Solé
Affiliation:
Hospital Clinic de Barcelona, Psychiatry, Barcelona, Spain
E. Jimenez
Affiliation:
Hospital Clinic de Barcelona, Psychiatry, Barcelona, Spain
C. Torrent
Affiliation:
Hospital Clinic de Barcelona, Psychiatry, Barcelona, Spain
C.D.M. Bonnin
Affiliation:
Hospital Clinic de Barcelona, Psychiatry, Barcelona, Spain
C. Varo
Affiliation:
Hospital Clinic de Barcelona, Psychiatry, Barcelona, Spain
R. Tabarés-Seisdedos
Affiliation:
University of Valencia – Cibersam – Incliva, Medicine, Valencia, Spain
V. Balanza-Martínez
Affiliation:
La Fe University and Polytechnic Hospital – University of Valencia – Cibersam, Department of Medicine, Valencia, Spain
E. Valls
Affiliation:
Hospital Clinic de Barcelona, Psychiatry, Barcelona, Spain
I. Morilla
Affiliation:
Hospital Clinic de Barcelona, Psychiatry, Barcelona, Spain
A.F. Carvalho
Affiliation:
Faculty of Medicine, Department of Clinical Medicine and Translational Psychiatry Research Group, Fortaleza, Brazil
J.L. Ayuso-Mateos
Affiliation:
Universidad Autónoma de Madrid – Cibersam, Department of Psychiatry, Madrid, Spain
E. Vieta
Affiliation:
Hospital Clinic de Barcelona, Psychiatry, Barcelona, Spain
A. Martinez-Aran
Affiliation:
Hospital Clinic de Barcelona, Psychiatry, Barcelona, Spain

Abstract

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Background

Cognitive reserve (CR) reflects the capacity of the brain to endure neuropathology, minimize clinical manifestations and successfully complete cognitive tasks. The present study aims to determine whether high CR may constitute a moderator of cognitive functioning in bipolar disorder (BD).

Methods

One hundred and two patients with BD and 32 healthy controls were enrolled. All patients met DSM-IV criteria for I or II BD and were euthymic (YMRS ≤ 6 and HDRS ≤ 8) during a 6-month period. All participants were tested with a comprehensive neuropsychological battery, and a Cerebral Reserve Score (CRS) was estimated. Subjects with a CRS below the group median were classified as having low CR, whereas participants with a CRS above the median value were considered to have high CR.

Results

Participants with BD with high CR displayed a better performance in measures of attention (digits forward: F = 4.554, P = 0.039); phonemic and semantic verbal fluency (FAS: F = 9.328, P = 0.004; and Animal Naming: F = 8.532, P = 0.006); and verbal memory (short cued recall of California Verbal Learning Test: F = 4.236, P = 0.046), after multivariable adjustment for potential confounders, including number of admissions and prior psychotic symptoms.

Conclusions

High cognitive reserve may therefore be a valuable construct to explore for predicting neurocognitive performance in patients with BD regarding premorbid status.

Disclosure of interest

Dr. I. Grande has received a Juan Rodés Contract (JR15/00012), Instituto de Salud Carlos III, Spanish Ministry of Economy and Competiveness, Barcelona, Spain and has served as a consultant for Ferrer and as a speaker for AstraZeneca, Ferrer and Janssen-Cilag.

Disclosure of interest

Dr. I. Grande has received a Juan Rodés Contract (JR15/00012), Instituto de Salud Carlos III, Spanish Ministry of Economy and Competiveness, Barcelona, Spain and has served as a consultant for Ferrer and as a speaker for AstraZeneca, Ferrer and Janssen-Cilag.

Type
e-Poster walk: Anxiety disorders and somatoform disorders
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S116
Copyright
Copyright © European Psychiatric Association 2017
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