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The genetics of affective disorder and suicide

Published online by Cambridge University Press:  16 April 2020

P. McGuffin ,
N. Perroud ,
R. Uher ,
A. Butlera ,
K.J. Aitchison ,
I. Craig ,
C. Lewis  and
A. Farmer
P. McGuffin*
Affiliation:
MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, DeCrespigny Park, LondonSE5 8AF, United Kingdom
N. Perroud
Affiliation:
MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, DeCrespigny Park, LondonSE5 8AF, United Kingdom
R. Uher
Affiliation:
MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, DeCrespigny Park, LondonSE5 8AF, United Kingdom
A. Butlera
Affiliation:
MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, DeCrespigny Park, LondonSE5 8AF, United Kingdom
K.J. Aitchison
Affiliation:
MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, DeCrespigny Park, LondonSE5 8AF, United Kingdom
I. Craig
Affiliation:
MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, DeCrespigny Park, LondonSE5 8AF, United Kingdom
C. Lewis
Affiliation:
MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, DeCrespigny Park, LondonSE5 8AF, United Kingdom
A. Farmer
Affiliation:
MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, DeCrespigny Park, LondonSE5 8AF, United Kingdom
*
*Corresponding author. E-mail address: [email protected] (P. McGuffin).
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Abstract

Suicidal behaviour shows evidence of familial clustering and the twin data on completed suicide suggest moderate heritability. The extent to which the genetics of suicidal behaviour overlaps with the genetics of affective disorders is unclear but there is overwhelming evidence that both bipolar and unipolar disorder are substantially influenced by genes. So far, candidate gene studies of suicidality have provoked much interest, but recently, attention has also turned to candidate gene approaches to suicidal ideation emerging during antidepressant treatment. The advent of genome-wide association studies (GWAS) has had a major impact on studies of affective disorder with some provocative new findings. The GWAS approach is also beginning to be applied in the search for genes that underlie suicidal ideation and behaviour.

Keywords

GeneticsSuicideGenome-wide association studies (GWAS)Affective disorder
Type
Original article
Information
European Psychiatry , Volume 25 , Issue 5: The role of genetics in promoting suicide prevention and the mental health of the population - Nobel Conference: The role of genetics in promoting suicide prevention and the mental health of the population , June 2010 , pp. 275 - 277
Copyright
Copyright © Elsevier Masson SAS 2010

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References

References

Bellivier, F, Chaste, P, Malafosse, AAssociation between the TPH gene A218C polymorphism and suicidal behavior: a metaanalysis. Am J Med Genet B Neuropsychiatr Genet 124B 2004 87–91.CrossRefGoogle Scholar
Bertelsen, A, Harvald, B, Hauge, MA Danish twin study of manic-depressive disorders. Br J Psychiatry 1977;130:330–351.CrossRefGoogle ScholarPubMed
Brezo, J, Bureau, A, Mérette, C, Jomphe, V, Barker, ED, Vitaro, Fet al.Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene-environment study. Mol Psychiatry 2009;21: [Epub ahead of print]Google Scholar
Courtet, P, Jollant, F, Castelnau, D, Buresi, C, Malafosse, ASuicidal behavior: relationship between phenotype and serotonergic genotype. Am J Med Genet C Semin Med Genet 133C 2005 25–33.CrossRefGoogle ScholarPubMed
Escriba, PV, Ozaita, A, Garcia-Sevilla, JAIncreased mRNA expression of alpha2A-adrenoceptors, serotonin receptors and mu-opioid receptors in the brains of suicide victims. Neuropsychopharmacology 2004;29:1512–1521.CrossRefGoogle ScholarPubMed
Farmer, A, Harris, T, Redman, K, Sadler, S, Mahmood, A, McGuffin, PThe Cardiff Depression Study - A sib pair study of life events and familiality in major depression. Br J Psychiatry 2000;176:150–155.CrossRefGoogle ScholarPubMed
Green, EK, Grozeva, D, Jones, I, Jones, L, Kirov, G, Caesar, Set al.The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia. Mol Psychiatry 2009;21: [Epub ahead of print]Google Scholar
Jones, I, Craddock, NBipolar disorder and childbirth: the importance of recognising risk. Br J Psychiatry 2005;186:453–454.CrossRefGoogle ScholarPubMed
Kendler, KS, Neale, MC, Kessler, RC, Heath, AC, Eaves, LJFamilial influences on the clinical characteristics of major depression: a twin study. Acta Psychiatr Scand 1992;86:371–378.CrossRefGoogle ScholarPubMed
Kendler, KS, Neale, MC, Kessler, RC, Heath, AC, Eaves, LJThe lifetime history of major depression in women: reliability of diagnosis and heritability. Arch Gen Psychiatry 1993;50:863–870.CrossRefGoogle ScholarPubMed
Laje, G, Paddock, S, Manji, H, Rush, AJ, Wilson, AF, Charney, Det al.Genetic markers of suicidal ideation emerging during citalopram treatment of major depression. Am J Psychiatry 2007;164:1530–1538.CrossRefGoogle ScholarPubMed
Li, D, He, LMeta-analysis supports association between serotonin transporter (5-HTT) and suicidal behavior. Mol Psychiatry 2007;12:47–54.10.1038/sj.mp.4001890CrossRefGoogle ScholarPubMed
Mann, JJNeurobiology of suicidal behaviour. Nat Rev Neurosci 2003;4:819–828.CrossRefGoogle ScholarPubMed
Marušič, A, Roskar, S, Hughes, RHFamilial study of suicide behaviour among adolescents in Slovenia. Crisis 2004;25:74–77.CrossRefGoogle ScholarPubMed
McGuffin, P, Katz, RNature, nurture and affective disorderDeakin, JWF, The Biology of Depression. London, UK: Gaskell; 1986. 25–51.Google Scholar
McGuffin, P, Katz, R, Rutherford, J, Watkins, SA hospital based twin register of the Heritability of DSM-IV Unipolar Depression. Arc Gen Psychiatry 1996;53:129–136.CrossRefGoogle ScholarPubMed
McGuffin, P, Rijsdijk, F, Andrew, M, Sham, P, Katz, R, Cardno, AThe heritability of bipolar affective disorder and the genetic relationship to unipolar depression. Arch Gen Psychiatry 2003;60:497–502.CrossRefGoogle ScholarPubMed
McGuffin, P, Knight, J, Breen, G, Brewster, S, Boyd, P, Craddock, Net al.Whole genome linkage scan of recurrent depressive disorder from the Depression Network Study. Hum Mol Genet 14(22)2005 3337–3345.10.1093/hmg/ddi363CrossRefGoogle ScholarPubMed
Muglia, P, Tozzi, F, Galwey, NW, Francks, C, UpmanyuR, , Kong, XQet al.Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts. Mol Psychiatry 2008[December 23: Epub ahead of print]Google ScholarPubMed
Perlis, RH, Purcell, S, Fava, M, Fagerness, J, Rush, AJ, Trivedi, MHet al.Association between treatment-emergent suicidal ideation with citalopram and polymorphisms near cyclic adenosine monophosphate response element binding protein in the STAR*D study. Arch Gen Psych 2007;64:689–697.CrossRefGoogle ScholarPubMed
Perroud, N, Courtet, P, Vincze, I, Jaussent, I, Jollant, F, Bellivier, Fet al.Interaction between BDNF Val66Met and childhood trauma on adults violent suicide attempt. Genes Brain Behav 2008;7:314–322.CrossRefGoogle ScholarPubMed
Perroud, N, Uher, R, Marusic, A, Rietschel, M, Mors, O, Henigsberg, Net al.Suicidal ideation during treatment of depression with escitalopram and nortriptyline in genome-based therapeutic drugs for depression (GENDEP): a clinical trial. BMC Med 2009;7:60.CrossRefGoogle ScholarPubMed
Rice, JP, Rochberg, N, Endicott, J, Lavori, PW, Miller, CStability of psychiatric diagnoses. An application to the affective disorders. Arch Gen Psychiatry 1992;49:824–830.CrossRefGoogle ScholarPubMed
Roy, A, Segal, NI, Centerwall, BS, Robinette, CDSuicide in twins. Arch Gen Psych 1991;48:28–32.10.1001/archpsyc.1991.01810250031003CrossRefGoogle ScholarPubMed
Sequeira, A, Mamdani, F, Lalovic, A, Anguelova, M, Lesage, A, Seguin, Met al.Alpha 2A adrenergic receptor gene and suicide. Psychiatry Res 2004;125:87–93.10.1016/j.psychres.2003.12.002CrossRefGoogle ScholarPubMed
Sklar, P, Smoller, JW, Fan, J, Ferreira, MA, Perlis, RH, Chambert, Ket al.Whole-genome association study of bipolar disorder. Mol Psychiatry 2008;13:558–569.CrossRefGoogle ScholarPubMed
Sullivan, PF, de Geus, EJ, Willemsen, G, James, MR, Smit, JH, Zandbelt, Tet al.Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. Mol Psychiatry 2009;14:359–375.CrossRefGoogle ScholarPubMed

Further reading

McGuffin, P, Marusic, A, Farmer, AWhat can psychiatric genetics offer suicidology? Crisis 2001;22:61–5.10.1027//0227-5910.22.2.61CrossRefGoogle ScholarPubMed
The Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3000 shared controls. Nature 2007;447:661–83.CrossRefGoogle Scholar
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