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Genetic influences on suicide and nonfatal suicidal behavior: Twin study findings

Published online by Cambridge University Press:  16 April 2020

N.L. Pedersen  and
A. Fiske
N.L. Pedersen
Affiliation:
Department of Medical Epidemiology and Biostatistics, Box 281, Karolinska Institutet, SE-171 77Stockholm, Sweden
A. Fiske*
Affiliation:
Department of Psychology, West Virginia University, PO Box 6040, Morgantown, West Virginia, 26506, USA
*
*Corresponding author. Tel.: +1 304 293 2001; fax: +1 304 293 6606. E-mail address: [email protected] (A. Fiske).
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Abstract

It has been well established that suicidal behavior is familial. Twin studies provide a unique opportunity to distinguish genetic effects from other familial influences. Consistent with findings from previous twin studies, including case series and selected samples, data from the population-based Swedish Twin Registry clearly demonstrate the importance of genetic influences on suicide. Twin studies of suicidal ideation and suicide attempts also implicate genetic influences, even when accounting for the effects of psychopathology. Future work is needed to evaluate the possibility of age and gender differences in heritability of suicide and nonfatal suicidal behavior.

Keywords

SuicideSuicidal ideationSuicide attemptConcordanceTwin studiesHeritability
Type
Original article
Information
European Psychiatry , Volume 25 , Issue 5: The role of genetics in promoting suicide prevention and the mental health of the population - Nobel Conference: The role of genetics in promoting suicide prevention and the mental health of the population , June 2010 , pp. 264 - 267
Copyright
Copyright © Elsevier Masson SAS 2010

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Footnotes

1

Tel.: +46 8 524 87418; fax: +46 8 31 49 75.

References

Boomsma, D, Busjahn, A, Peltonen, LClassical twin studies and beyond. Nat Rev Genet 2002;3:872–882.10.1038/nrg932CrossRefGoogle ScholarPubMed
Brent, DA, Melhem, NFamilial transmission of suicidal behavior. Psychiatr Clin North Am 2008;31:157–177.10.1016/j.psc.2008.02.001CrossRefGoogle ScholarPubMed
Cho, H, Guo, G, Iritani, BJ, Hallfors, DDGenetic contribution to suicidal behaviors and associated risk factors among adolescents in the US. Prev Sci 2006;7:303–311.10.1007/s11121-006-0042-5CrossRefGoogle Scholar
Fu, Q, Heath, AC, Bucholz, KK, Nelson, EC, Glowinski, AL, Goldberg, Jet al.A twin study of genetic and environmental influences on suicidality in men. Psychol Med 2002;32:11–24.10.1017/S0033291701004846CrossRefGoogle ScholarPubMed
Glowinski, AL, Bucholz, KK, Nelson, EC, Fu, Q, Madden, PAF, Reich, Wet al.J Am Acad Child Adolesc Psychiatry 2001;40:1300–1307.10.1097/00004583-200111000-00010CrossRefGoogle Scholar
Juel-Nielsen, N, Videbech, TA twin study of suicide. Acta Genet Med Gemellol 1970;19:307–310.10.1017/S1120962300025774CrossRefGoogle ScholarPubMed
Kendler, KS, Gatz, M, Gardner, CO, Pedersen, NLA Swedish national twin study of lifetime major depression. Am J Psychiatry 2006;163:109–114.10.1176/appi.ajp.163.1.109CrossRefGoogle ScholarPubMed
Kendler, KS, Prescott, CAGenes, environment, and psychopathology. New York: Guilford; 2006.Google Scholar
Lichtenstein, P, Sullivan, PF, Cnattingius, S, Gatz, M, Johansson, S, Carlström, Eet al.The Swedish Twin Registry in the Third Millennium: an update. Twin Res Hum Genet 2006;9:875–882.10.1375/twin.9.6.875CrossRefGoogle ScholarPubMed
McGue, MWhen assessing twin concordance, use the probandwise not the pairwise rate. Schizophr Bull 1992;18:171–176.10.1093/schbul/18.2.171CrossRefGoogle Scholar
McGuffin, P, Marusic, A, Farmer, AWhat can psychiatric genetics offer suicidology?. Crisis 2001;22:61–65.10.1027//0227-5910.22.2.61CrossRefGoogle ScholarPubMed
Nock, MK, Borges, G, Bromet, EJ, Cha, CB, Kessler, RC, Lee, SSuicide and suicidal behavior. Epidemiol Rev 2008;30:133–154.10.1093/epirev/mxn002CrossRefGoogle ScholarPubMed
Rockett, IRH, Thomas, BMReliability and sensitivity of suicide certification in higher-income countries. Suicide Life Threat Behav 1999;29:141–149.Google ScholarPubMed
Roy, A, Rylander, G, Forslund, K, Asberg, M, Mazzanti, CM, Goldman, Det al.Excess tryptophan hydroxylase 17 779C allele in surviving cotwins of monozygotic twin suicide victims. Neuropsychobiology 2001;43:233–236.10.1159/000054895CrossRefGoogle ScholarPubMed
Roy, A, Segal, NLSuicidal behavior in twins: a replication. J Affect Disord 2001;66:71–74.10.1016/S0165-0327(00)00275-5CrossRefGoogle ScholarPubMed
Roy, A, Segal, NL, Centerwall, BS, Robinette, CDSuicide in twins. Arch Gen Psychiatry 1991;48:29–32.10.1001/archpsyc.1991.01810250031003CrossRefGoogle ScholarPubMed
Roy, A, Segal, NL, Sarchiapone, MAttempted suicide among living co-twins of twin suicide victims. Am J Psychiatry 1995;152:1075–1076.Google ScholarPubMed
Segal, NL, Roy, ASuicidal attempts and ideation in twins whose co-twin deaths were non-suicides: replication and elaboration. Pers Individ Dif 2001;31:445–452.10.1016/S0191-8869(00)00149-5CrossRefGoogle Scholar
Statham, DJ, Heath, AC, Madden, PAF, Bucholz, KK, Beirut, L, Dinwiddie, SHet al.Psychol Med 1998;28:839–855.10.1017/S0033291798006916CrossRefGoogle Scholar
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