Hostname: page-component-cd9895bd7-7cvxr Total loading time: 0 Render date: 2024-12-28T11:35:01.266Z Has data issue: false hasContentIssue false

Gender-related effect of parental age on age-at-onset in bipolar disorder

Published online by Cambridge University Press:  16 April 2020

M. Grigoroiu-Serbanescu
Affiliation:
Psychiatric Genetics Research Unit, Alexandru Obregia Psychiatric Hospital, Bucharest, Romania
P. Wickramaratne
Affiliation:
Columbia University, New York State Psychiatric Institute, New York, NY, USA
M.M. Noethen
Affiliation:
Institute of Medical Genetics, University of Bonn, Bonn, Germany

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Aim:

We investigated the effect of the parental age at child birth on the age-of-onset (AO) of bipolar disorder in a sample of 336 bipolar I patients directly interviewed with DIGS (DSM-IV-R criteria) in connection with the type of family history (FH): 1) no family history of major psychoses (sporadic); 2) only recurrent unipolar major depression (MDD-RUP); 3) bipolar disorder, schizoaffective disorders or schizophrenia (BP/SA/SCHIZ).

Method:

Familial psychopathology data were collected through direct interview about 76% of first-degree relatives and through FH-method (FIGS-interview) about first- and second-degree relatives not available to direct investigation.

Results:

Linear/logistic regressions showed a significant effect of the paternal age (PATAGE) on AO in offspring in the total sample (p=0.040); PATAGE was negatively correlated with AO in offspring when interacting with the proband gender (p=0.026) and FH-type (p=0.003). The division of the patients by sex revealed a significant association between PATAGE and AO only in females (p=0.003); the fathers of females with FH of MDD-RUP and the fathers of sporadic females were significantly older than the fathers of females with FH of BP/SA/SCHIZ. The first two groups generated the negative correlation appearing in the total sample. No correlation between PATAGE and proband AO was observed in the third group. Maternal age had no impact on AO in offspring.

Conclusion:

The PATAGE effect on AO in bipolar offspring was related to female sex and FH-type and it was detectable in bipolar probands with no familial loading or with milder loading like the MDD-RUP.

Type
Poster Session 2: Bipolar Disorders
Copyright
Copyright © European Psychiatric Association 2007
Submit a response

Comments

No Comments have been published for this article.