Hostname: page-component-cd9895bd7-jn8rn Total loading time: 0 Render date: 2024-12-26T14:04:16.385Z Has data issue: false hasContentIssue false
  • English
  • Français

Fluid-attenuated inversion-recovery MR imaging in schizophrenia-associated with idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome)

Published online by Cambridge University Press:  16 April 2020

Tsuyoshi Miyaoka ,
Rei Yasukawa ,
Takumi Mihara ,
Shoichi Mizuno ,
Hideaki Yasuda ,
Tsuruhei Sukegawa ,
Maiko Hayashida ,
Takuji Inagaki  and
Jun Horiguchi
Tsuyoshi Miyaoka*
Affiliation:
Department of Psychiatry, Shimane University School of Medicine, 89-1 Enyacho, Izumo693-8501, Japan
Rei Yasukawa
Affiliation:
Department of Psychiatry, Shimane University School of Medicine, 89-1 Enyacho, Izumo693-8501, Japan
Takumi Mihara
Affiliation:
Department of Psychiatry, Shimane University School of Medicine, 89-1 Enyacho, Izumo693-8501, Japan
Shoichi Mizuno
Affiliation:
Department of Psychiatry, Shimane University School of Medicine, 89-1 Enyacho, Izumo693-8501, Japan
Hideaki Yasuda
Affiliation:
Department of Psychiatry, Shimane University School of Medicine, 89-1 Enyacho, Izumo693-8501, Japan
Tsuruhei Sukegawa
Affiliation:
Department of Psychiatry, Shimane University School of Medicine, 89-1 Enyacho, Izumo693-8501, Japan
Maiko Hayashida
Affiliation:
Department of Psychiatry, Shimane University School of Medicine, 89-1 Enyacho, Izumo693-8501, Japan
Takuji Inagaki
Affiliation:
Department of Psychiatry, Shimane University School of Medicine, 89-1 Enyacho, Izumo693-8501, Japan
Jun Horiguchi
Affiliation:
Department of Psychiatry, Shimane University School of Medicine, 89-1 Enyacho, Izumo693-8501, Japan
*
*Corresponding author. Tel.: +81 853 20 2263; fax: +81 853 20 2260. E-mail address: [email protected] (T. Miyaoka).
Get access

Abstract

Background

Patients with schizophrenia show a significantly higher frequency of hyperbilirubinemia the patients suffering from other psychiatric disorders and the general healthy population. The objective of the current study was to determine whether patients with schizophrenia-associated idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome, GS) have specific changes in signal intensities on fluid-attenuated inversion-recovery (FLAIR) magnetic resonance (MR) images.

Methods

Axial 5-mm-thick FLAIR MR images from schizophrenia patients with GS (n = 18) and schizophrenia patients without GS (n = 18), all diagnosed according to DSM-IV criteria, were compared with age- and sex-matched non-psychiatric controls (n = 18). Signal intensities in the hippocampus, amygdala, caudate, putamen, thalamus, cingulate gyrus, and insula were graded relative to cortical signal intensity in the frontal lobe.

Results

Compared to both schizophrenia patients without GS and normal controls, the schizophrenia patients with GS showed significantly increased signal intensities in almost all regions studied.

Conclusion

Patients with schizophrenia-associated GS have specific changes of signal intensities on FLAIR MR images, suggesting that schizophrenia with GS produces changes in the fronto-temporal cortex, limbic system, and basal ganglia.

Keywords

Fluid-attenuated inversion-recoveryMR imagingGilbert's syndromeSchizophrenia
Type
Original article
Information
European Psychiatry , Volume 20 , Issue 4 , June 2005 , pp. 327 - 331
Copyright
Copyright © Elsevier SAS 2005

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Adachi, Y, Nanno, T, Yamamoto, TJapanese clinical statistical data of patients with constitutional jaundice (in Japanese). Nippon Rinsho. 1998;50:677–685.Google Scholar
American Psychiatric Association. Diagnostic and statistical manual of mental disorders, fourth ed. Washington, DC: American Psychiatric Press; 1994.Google Scholar
Andreasen, NC, Ehrhardt, JC, Swayze, VW, Alliger, RJ, Yah, WT, Cohen, Get al.Magnetic resonance imaging of the brain in schizophrenia. Arch Gen Psychiatry 1990;47:35–44.CrossRefGoogle Scholar
Andreasen, NC, Swayze, VW, Flaum, M, Yates, WR, Arndt, S, McChesney, CVentricular enlargement in schizophrenia evaluated with computed tomographic scanning. Arch Gen Psychiatry 1990;47:1008–1015.CrossRefGoogle ScholarPubMed
Conlee, JW, Shapiro, SM, Churn, SBExpression of the a and b subunits of Ca2+/calmodulin kinase II in the cerebellum of jaundiced Gunn rats during development: a quantitative light microscopic analysis. Acta Neuropathol (Berl) 2000;99:393–401.CrossRefGoogle Scholar
Dalman, C, Cullberg, JNeonatal hyperbilirubinemia—a vulnerability factor for mental disorder?. Acta Psychiatr Scand 1999;1000:469–471.CrossRefGoogle Scholar
Gilbert, A, Lereboullet, PLa cholermie simple familiale. Sem Med 1901;21:241–245.Google Scholar
Hulshoff Pol, HE, Schnack, HG, Mandl, RC, Van Haren, NE, Koning, H, Collins, DLet al.Focal gray matter density changes in schizophrenia. Arch Gen Psychiatry 2001;58:1118–1125.CrossRefGoogle Scholar
McDonald, JW, Shapiro, SM, Silverstein, FS, Johnston, MVRole of glutamate receptor-mediated excitotoxicity in bilirubin-induced brain injury in the Gunn rat model. Exp Neurol 1998;150:21–29.CrossRefGoogle ScholarPubMed
Miyaoka, T, Seno, H, Itoga, M, Maeda, T, Horiguchi, JSchizophrenia-associated idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome): three case reports. J Clin Psychiatry 2000;61:299–300.CrossRefGoogle Scholar
Miyaoka, T, Seno, H, Itoga, M, Iijima, M, Inagaki, T, Horiguchi, JSchizophrenia-associated idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome). J Clin Psychiatry 2000;61:868–871.CrossRefGoogle Scholar
Miyaoka, T, Seno, H, Itoga, M, Inagaki, T, Horiguchi, JStructural brain changes in schizophrenia associated with idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome): a planimetric CT study. Schizophr Res 2001;52:291–293.CrossRefGoogle ScholarPubMed
Miyaoka, T, Yasukawa, R, Mizuno, S, Sukegawa, T, Inagaki, T, Inagaki, Tet al.Clinical features of schizophrenia associated with idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome). Int J Psychol Clin Pract 2003;7:199–203.CrossRefGoogle Scholar
Muller, N, Schiller, P, Ackenheil, MCoincidence of schizophrenia and hyperbilirubinemia. Pharmacopsychiatry 1991;24:225–228.CrossRefGoogle ScholarPubMed
Northoff, G, Waters, H, Mooren, I, Schluter, U, Diekmann, S, Falkai, Pet al.Cortical sulcal enlargement in catatonic schizophrenia: a planimetric CT study. Psychiat Res Neuroimag 1999;91:45–54.CrossRefGoogle ScholarPubMed
Okuda, T, Korogi, Y, Shigematsu, Y, Sugahara, T, Hirai, T, Ikushima, Iet al.Brain lesions: when should fluid-attenuated inversion-recovery sequences be used in MR evaluation?. Radiology 1999;22:793–798.CrossRefGoogle Scholar
Otsuji, S, Mizuno, K, Ito, Set al.A new enzymatic approach for estimating total and direct bilirubin. Clin Biochem 1988;21:33–38.CrossRefGoogle ScholarPubMed
Owens, D, Evans, JPopulation studies of Gilbert's syndrome. J Med Genet 1998;12:152–156.CrossRefGoogle Scholar
Sawasaki, Y, Yamada, N, Nakajima, HDevelopmental features of cerebellar hypoplasia and brain bilirubin levels in a mutant (Gunn) rat with hereditary hyperbilirubinemia. J. Neurochem. 1976;27:577–583.CrossRefGoogle Scholar
Usui, N, Matsuda, K, Mihara, T, Tottori, T, Ohtsubo, T, Baba, Ket al.MRI of cortical dysplasia correlation with pathological findings. Neuroradiology 2001;43:830–837.CrossRefGoogle ScholarPubMed
Woods, D, Yurgelun-Todd, D, Goldstein, J, Seidman, L, Tsuang, MMRI brain abnormalities in chronic schizophrenia: one process or more?. Biol Psychiatry. 1996;40:585–596.CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.