Hostname: page-component-78c5997874-4rdpn Total loading time: 0 Render date: 2024-11-07T23:24:49.402Z Has data issue: false hasContentIssue false
  • English
  • Français

Feasibility of pharmacotherapy in HIV-related affective spectrum disorders: an open trial with fluvoxamine

Published online by Cambridge University Press:  16 April 2020

P Perretta ,
C Nisita ,
E Zaccagnini ,
C Lorenzetti ,
A Nuccorini ,
GB Cassano ,
DM McNair  and
HS Akiskal
P Perretta
Affiliation:
Psychiatric Clinic I, University of Pisa Via Roma 56, 56100Pisa, Italy
C Nisita
Affiliation:
Psychiatric Clinic I, University of Pisa Via Roma 56, 56100Pisa, Italy
E Zaccagnini
Affiliation:
Psychiatric Clinic I, University of Pisa Via Roma 56, 56100Pisa, Italy
C Lorenzetti
Affiliation:
Psychiatric Clinic I, University of Pisa Via Roma 56, 56100Pisa, Italy
A Nuccorini
Affiliation:
Psychiatric Clinic I, University of Pisa Via Roma 56, 56100Pisa, Italy
GB Cassano*
Affiliation:
Psychiatric Clinic I, University of Pisa Via Roma 56, 56100Pisa, Italy
DM McNair
Affiliation:
Boston University, Boston, MA
HS Akiskal
Affiliation:
University of California at San Diego, San Diego, CA, USA
*
*Correspondence and reprints.
Get access

Summary

Among HIV patients treated for AIDS-related adjustment, major depressive disorders and other affective disorders, we assessed in an open study the feasibility of using a serotonergic antidepressant (fluvoxamine). Thirty-five seropositive patients with the above conditions (22 men and 13 women) were followed over a minimum period of four weeks. At the end of the treatment, a large number of patients (77%) showed marked improvement. “Nuclear” depressive and anxiety symptoms remitted, while the “somatic” ones seemed less sensitive to treatment. Treatment had to be terminated prematurely due to side effects in only two patients (6%).

Keywords

fluvoxaminetreatmentHIV patientsaffective spectrum disordersorganic mood disorder
Type
Original article
Information
European Psychiatry , Volume 11 , Issue 1 , 1996 , pp. 40 - 45
Copyright
Copyright © 1996 Elsevier, Paris

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Abrams, DJDilley, JWMaxey, LMVolberding, PARoutine care and psychosocial support of the patient with AIDS. Med Clin North Am 1986; 70: 707–720CrossRefGoogle Scholar
American Psychiatric Association, 3rd ed, rev.Diagnostic and Statistical Manual of Mental Disorders 1987 American Psychiatric Association Washington, DCGoogle Scholar
Buhrich, NCooper, DAFreed, EHIV infection associated with symptoms indistinguishable from functional psychosis. Br J Psychiatry 1988; 152: 649–653CrossRefGoogle ScholarPubMed
Burack, JHBarren, DCStall, RDChesney, MADepressive symptoms and CD4 lymphocite decline among HIV-infected men. JAMA 1993; 270: 2568–2573CrossRefGoogle Scholar
Calabrese, JRKling, MAGold, PVAlterations in immunocompetence during stress, bereavement, and depression: focus on neuroendocrine regulation. Am J Psychiatry 1987; 144: 1123–1134Google ScholarPubMed
Centers for Disease Control Update. Acquired Immunodeficiency Syndrome (AIDS). MMWR 1986; 35: 757–760Google Scholar
Colon, EANeuropsychiatric aspects of infection with the human immunodeficiency virus. Curr Opin Psychiatry 1988; 1: 5–12CrossRefGoogle Scholar
Curran, VHSakulsripron, MLader, MAntidepressant and human memory: an investigation of four drugs with different sedative and anticholinergic profiles. Psychopharmacology 1988; 95: 520–527Google ScholarPubMed
Darko, DFMc Cutchan, JAKripke, DFGillin, JCGolshan, SFatigue, sleep disturbance, disability, and indices of progression of HIV infection. Am J Psychiatry 1992; 149: 514–520Google ScholarPubMed
Derix, MMAde Gans, JStam, JPortegies, PMental changes in patients with AIDS. Clin Neurol Neurosurg 1990; 92: 215–222CrossRefGoogle ScholarPubMed
Egan, VBrettle, RPGoodwin, GMThe Edinbourgh cohort of HIV-positive drug users: pattern of cognitive impairment in relation to progression of disease. Br J Psychiatry 1992; 161: 522–531CrossRefGoogle Scholar
Faulstich, MEPsychiatric aspects of AIDS. Am J Psychiat 1987; 144: 551–556Google Scholar
Fernandez, FAdams, FLevy, JKCognitive impairmant due to AIDS-related complex and its response to psychostmulants Psychosomatics 1988 37 12351238Google Scholar
Fernandez, FLevy, JKMansel, PWAResponse to antidepressant therapy in depressed persons with advanced HTV infectionPoster presented at V international conference on AIDS (Montreal) WBP Houston, Texas USAAnderson Cancer Center 1989 191Google Scholar
Folstein, MFFolstein, SEMac Hugh, PRMini Mental State: a practical method for grading the cognitive state of patients for the clinicians. J Psychiar Re 1975; 12: 189–198CrossRefGoogle Scholar
Gazbuda, DHHo, DDDe La Monte, SMImmunohistochemical identification of HTLV-III antigen in brains of patients with AIDS Ann Neurology 20 1986 289295Google Scholar
GIAIDS, Giornale Italiano dll'AIDS 1993 3 129139Google Scholar
Goldberg, RJMor, VA survey of psychotropic use in terminal cancer patients Psychosomatics 26 1986 745CrossRefGoogle Scholar
Goodkin, KPsychiatric disorders in HTV spectrum illness. Texas Medicine 1988; 84: 55–60Google Scholar
Lapierre, YDBrowne, HonTreatment of Major Affective Disorders with fluvoxamine. J Clin Psych 1987; 48: 65–68Google ScholarPubMed
Levine, SHAnderson, DBystritsky, AThe treatment and evaluation of depression in patients infected with HIVCME Syllabus and Proceedings Summary, 143rd Annual Meeting of the American Psychiatric Association Washington, DCAPA 1990Google Scholar
Levy, JAScimabukuro, JHollander, HMills, JKaminsky, LIsolation of AIDS-associated retroviruses from cerebrospinal fluid and brain of patients with neurological symptoms Lancet II 1985 586588Google Scholar
Lyketsos, CGHoover, DRGruccione, MSenterfitt, WDepressive symptoms as predictors of medical outcomes in HIV infections. JAMA 1993; 270: 2563–2567CrossRefGoogle Scholar
Maj, MOrganic mental disorders in HIV-1 infection. AIDS 1990; 4: 831–840CrossRefGoogle ScholarPubMed
Maj, MPsychiatric aspects of HIV-1 infection and AIDS. Psychol Med 1990; 20: 547–563CrossRefGoogle ScholarPubMed
McDonald, EMMann, AHThomas, HCInterferons as mediators of psychiatric morbidity. An investigation in an trial of recombinant interferon in hepatitis-B carriers. Lancet 1987; 2: 1175–1178CrossRefGoogle Scholar
Munoz, ACarey, VSaah, APredictors of decline in CD4 lymphocytes in a cohort of homosexual men infected with human immunodeficency virus J Acquired Immune Deficiency Syndromes 1988 1 396404Google Scholar
Ochitil, HDilley, JKohlwes, JPsychotropic drug prescribing for hospitalized patients with Acquired Immunodeficiency Syndrome. Am J Med 1991; 90: 601–605CrossRefGoogle Scholar
Overall, JGorham, DBrief Psychiatric Rating Scale. Psychol Rep 1962; 10: 799–822CrossRefGoogle Scholar
Perry, SJacobsen, PNeuropsychiatric manifestations of AIDSspectrum disorders. Hospital Community Psychiatry 1986; 37: 135–142Google ScholarPubMed
Perry, SWOrganic Mental Disorders caused by HIV: update on early diagnosis and treatment. Am J Psychiatry 1990; 147: 696–710Google ScholarPubMed
Popkin, MCallies, AMackenzie, TThe outcome of antidepressant use in the medically ill. Arch Gen Psychiatry 1985; 42: 1160–1163CrossRefGoogle ScholarPubMed
Rabkin, JGHarrison, MPHHarrison, WHEffect of Imipramine on depression and immune status in a sample of men with HIV infection. Am J Psychiatry 1990; 147: 495–497Google Scholar
Rosenstein, DLTakeshita, JNelson, JCFluoxetine Treatment of depression in patients with HIV infection Am J Psychiatry 148 1991 6Google Scholar
Seth, RGranville-Grossman, KGoldmeier, DLynch, SPsychiatric illness in patients with HIV infection and AIDS referred to the liasison psychiatrists. Br J Psychiatry 1991; 159: 347–350CrossRefGoogle Scholar
Storch, DDCaution with use of tricyclics in patients with AIDS Am J Psychiatry 1991 148 12Google ScholarPubMed
Udelman, DUdelman, HA preliminary report on antidepressant therapy and its effects on hope and immunity. Soc Sci Med 1985; 20: 1069–1072CrossRefGoogle ScholarPubMed
Wolcott, DLFawzy, HPasnau, ROAIDS and consultation liason psychiatry. Gen Hosp Psychiatry 1986; 8: 7–10Google Scholar
Wolcott, DLPsychosocial aspects of acquired immune deficiency syndrome and the primary care physician. Ann Allergy 1986; 57: 95–102Google ScholarPubMed
Zovy, WCGI: Clinical Global Impression ECDEU Assessment Manual for Psychopharmacology RevisedDHEW Publication No (ADM) RockvilleNational Institute of Mental Health 1976Google Scholar
Submit a response

Comments

No Comments have been published for this article.