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Fatal interaction between tranylcypromine and imipramine

Published online by Cambridge University Press:  16 April 2020

Wim Otte ,
Tom K. Birkenhager  and
Walter W. van den Broek
Wim Otte
Affiliation:
Emergis Centre for Mental Health, Goes, The Netherlands
Tom K. Birkenhager*
Affiliation:
Department of psychiatry, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
Walter W. van den Broek
Affiliation:
Department of psychiatry, Erasmus Medical Centre, Dr. Molewaterplein 403015GD, Rotterdam, The Netherlands
*
2Corresponding author. Present address: Dept. of Psychiatry, Erasmus MC, P.O. Box 2040, 3000 CA Rotterdam, the Netherlands. [email protected]
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Extract

This case report describes a patient on tranylcypromine who erroneously received a single dose of imipramine and subsequently developed a fatal serotonin syndrome. Both the clinical features and the pathophysiology of the serotonin syndrome are discussed.

Keywords

TranylcypromineImipramineDepressionSerotonin syndrome
Type
Case report
Information
European Psychiatry , Volume 18 , Issue 5 , August 2003 , pp. 264 - 265
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS 2003

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